MD simulations indicate Omicron P132H of SARS-CoV-2 M is a potential allosteric mutant involved in modulating the dynamics of catalytic site entry loop.

The SARS-CoV-2 main protease M, essential for viral replication is an important drug target. It plays a critical role in processing viral polyproteins necessary for viral replication assembly. One of the predominant SARS-CoV-2 M mutations of Omicron variant is Pro132His.