Publications by authors named "Mohd Fadzli Mustaffa Khairul"
Elevated serum soluble programmed death ligand 1 (sPD-L1) level correlate with clinical characteristics in breast cancer patients: A study at Hospital Universiti Sains Malaysia.
Cytokine
October 2024
Article Synopsis
- - The study aimed to investigate serum levels of soluble PD-L1 (sPD-L1) in breast cancer patients, specifically focusing on Asian (Malay) women, and its correlation with various clinical characteristics.
- - Blood samples were collected from 92 malignant and 16 benign breast cancer patients, as well as 23 healthy controls, revealing that sPD-L1 levels were significantly higher in the cancer groups compared to healthy individuals.
- - The findings indicated that sPD-L1 levels were linked to factors like age at menarche, ethnicity, birth control usage, and HER2 status, highlighting the need for further research on sPD-L1's role in breast cancer diagnosis and progression.
Recent advancement in molecular medicine has seen applications of advanced biotechnology tools such as aptamer technology in therapeutics and diagnostics. Aptamer technology has witnessed various approaches including "Click-Chemistry" towards modifying aptamer structure to improve its potentials, but limited studies have reported the influence of such alteration on aptamer's specificity and affinity for their targets. Here, we utilized square wave voltammetry (SWV) electrochemical sensing based on heme to show the effects of cholesterol-triethylene-glycol (COL-TEG) modification of protoporphyrin-IX DNA-aptamers (OKA_24 and OKA_26) on their affinity for heme.
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- * Cytoadherence, the process where infected cells stick to blood vessel walls, may contribute to severe malaria by blocking microcirculation.
- * This review aims to explore whether cytoadherence is essential for developing severe malaria by examining existing research on its role in the disease's pathology.
Fluoxetine (FLX), a P-glycoprotein inhibitor with antimalarial activity, is promising candidate for reversing chloroquine/mefloquine (CQ/MQ) resistance. The Dd2 strain of CQ- and MQ-resistant Plasmodium falciparum was synchronized and assayed with various concentrations of CQ/MQ individually and in combination with FLX or verapamil (VPL). Our results indicated the 50% inhibitory concentration values of CQ and MQ were greatly lowered when FLX was used simultaneously.
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