Stacking with Recursive Feature Elimination-Isolation Forest for classification of diabetes mellitus.

Diabetes Mellitus is one of the oldest diseases known to humankind, dating back to ancient Egypt. The disease is a chronic metabolic disorder that heavily burdens healthcare providers worldwide due to the steady increment of patients yearly. Worryingly, diabetes affects not only the aging population but also children.

Artificial Bee Colony algorithm in estimating kinetic parameters for yeast fermentation pathway.

Analyzing metabolic pathways in systems biology requires accurate kinetic parameters that represent the simulated processes. Simulation of the fermentation pathway in the kinetic model help saves much time in the optimization process. Fitting the simulated model into the experimental data is categorized under the parameter estimation problem.

gene knockout prediction using a hybrid of Bat algorithm and minimization of metabolic adjustment.

Microorganisms commonly produce many high-demand industrial products like fuels, food, vitamins, and other chemicals. Microbial strains are the strains of microorganisms, which can be optimized to improve their technological properties through metabolic engineering. Metabolic engineering is the process of overcoming cellular regulation in order to achieve a desired product or to generate a new product that the host cells do not usually need to produce.

Breast cancer disease classification using fuzzy-ID3 algorithm with FUZZYDBD method: automatic fuzzy database definition.

Breast cancer becomes the second major cause of death among women cancer patients worldwide. Based on research conducted in 2019, there are approximately 250,000 women across the United States diagnosed with invasive breast cancer each year. The prevention of breast cancer remains a challenge in the current world as the growth of breast cancer cells is a multistep process that involves multiple cell types.

Comparison of Optimization-Modelling Methods for Metabolites Production in Escherichia coli.

The metabolic network is the reconstruction of the metabolic pathway of an organism that is used to represent the interaction between enzymes and metabolites in genome level. Meanwhile, metabolic engineering is a process that modifies the metabolic network of a cell to increase the production of metabolites. However, the metabolic networks are too complex that cause problem in identifying near-optimal knockout genes/reactions for maximizing the metabolite's production.

Topologically significant directed random walk with applied walker network in cancer environment.

Numerous cancer studies have combined different datasets for the prognosis of patients. This study incorporated four networks for significant directed random walk (sDRW) to predict cancerous genes and risk pathways. The study investigated the feasibility of cancer prediction via different networks.

Missing-Values Imputation Algorithms for Microarray Gene Expression Data.

In gene expression studies, missing values are a common problem with important consequences for the interpretation of the final data (Satija et al., Nat Biotechnol 33(5):495, 2015). Numerous bioinformatics examination tools are used for cancer prediction, including the data set matrix (Bailey et al.

Identifying a Gene Knockout Strategy Using a Hybrid of Simple Constrained Artificial Bee Colony Algorithm and Flux Balance Analysis to Enhance the Production of Succinate and Lactate in Escherichia Coli.

In recent years, metabolic engineering has gained central attention in numerous fields of science because of its capability to manipulate metabolic pathways in enhancing the expression of target phenotypes. Due to this, many computational approaches that perform genetic manipulation have been developed in the computational biology field. In metabolic engineering, conventional methods have been utilized to upgrade the generation of lactate and succinate in E.

An enhanced topologically significant directed random walk in cancer classification using gene expression datasets.

Microarray technology has become one of the elementary tools for researchers to study the genome of organisms. As the complexity and heterogeneity of cancer is being increasingly appreciated through genomic analysis, cancerous classification is an emerging important trend. Significant directed random walk is proposed as one of the cancerous classification approach which have higher sensitivity of risk gene prediction and higher accuracy of cancer classification.

A newton cooperative genetic algorithm method for in silico optimization of metabolic pathway production.

This paper presents an in silico optimization method of metabolic pathway production. The metabolic pathway can be represented by a mathematical model known as the generalized mass action model, which leads to a complex nonlinear equations system. The optimization process becomes difficult when steady state and the constraints of the components in the metabolic pathway are involved.