Publications by authors named "Mohd Anuar Md Ali"
We employed dielectrophoresis to a yeast cell suspension containing amyloid-beta proteins (Aβ) in a microfluidic environment. The Aβ was separated from the cells and characterized using the gradual dissolution of Aβ as a function of the applied dielectrophoretic parameters. We established the gradual dissolution of Aβ under specific dielectrophoretic parameters.
View Article and Find Full Text PDFThis paper presents the development and experimental analysis of a curved microelectrode platform for the DEP deformation of breast cancer cells (MDA-MB-231). The platform is composed of arrays of curved DEP microelectrodes which are patterned onto a glass slide and samples containing MDA-MB-231 cells are pipetted onto the platform's surface. Finite element method is utilised to characterise the electric field gradient and DEP field.
View Article and Find Full Text PDFArticle Synopsis
- - The study focuses on
- cell contact formation
- , a crucial process in biotechnology, which can be enhanced using
- dielectrophoresis (DEP)
- —a straightforward technique for manipulating cells. - Researchers demonstrate how optimizing
- DEP microelectrode configurations
- can minimize harmful effects like dielectric heating, improve cell clustering, and move away from traditional linear arrangements of cells. - The research combines
- experimental work and mathematical modeling
- with COMSOL to explore capillary-based microfluidic systems, offering new protocols for cell manipulation that could benefit areas like diagnostics and understanding cellular interactions.
The recent advancement of dielectrophoresis (DEP)-enabled microfluidic platforms is opening new opportunities for potential use in cancer disease diagnostics. DEP is advantageous because of its specificity, low cost, small sample volume requirement, and tuneable property for microfluidic platforms. These intrinsic advantages have made it especially suitable for developing microfluidic cancer diagnostic platforms.
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