Ethyl 4-[(2-hy-droxy-eth-yl)amino]-2-(4-meth-oxyphen-yl)-1-methyl-5-oxo-2,5-di-hydro-1-pyrrole-3-carboxyl-ate.

In the title compound, CHNO the pyrrolidine ring is almost planar and subtends a dihedral angle of 85.77 (7)° with the pendant phenyl ring. An intra-molecular N-H⋯O hydrogen bond generates an (6) loop.

Methyl 2-[()-5-methyl-2-oxoindolin-3-yl-idene]hydrazinecarbodi-thio-ate.

The title di-thio-carbazate imine, CHNOS, was obtained from the condensation reaction of -methyl-dithio-carbazate (SMDTC) and 5-methyl-isatin. It shows a configuration about the imine C=N bond, which is associated with an intra-molecular N-H⋯O hydrogen bond that closes an (6) ring. In the crystal, inversion dimers linked by pairwise N-H⋯O hydrogen bonds generate (8) loops.

Ethyl (2,3,4)-1-ethyl-2-(furan-2-yl)-4-hy-droxy-5-oxopyrrolidine-3-carboxyl-ate.

The title racemic oxopyrrolidine compound, CHNO, contains three stereogenic centres and crystallizes with two mol-ecules in the asymmetric unit. The five-membered pyrrolidine rings in both mol-ecules exhibit envelope conformations. The -ethyl group of one of the mol-ecules is disordered over two sets of sites in a 0.

Methyl 2-[()-5-bromo-2-oxoindolin-3-yl-idene]-hydrazinecarbodi-thio-ate.

The title compound, CHBrNOS, a brominated di-thio-carbazate imine deriv-ative, was obtained from the condensation reaction of -methyl-dithio-carbazate (SMDTC) and 5-bromo-isatin. The essentially planar mol-ecule exhibits a configuration, with the di-thio-carbazate and 5-bromo-isatin fragments located on the same sides of the C=N azomethine bond, which allows for the formation of an intra-molecular N-H⋯O (b = bromo-isatin) hydrogen bond generating an (6) ring motif. In the crystal, adjacent mol-ecules are linked by pairs of N-H⋯O hydrogen bonds, forming dimers characterized by an (8) loop motif.

4-Fluoro-benzyl ()-2-(2-oxoindolin-3-yl-idene)hydrazine-1-carbodi-thio-ate.

The title compound, CHFNOS, a fluorinated di-thio-carbazate imine derivative, was synthesized by the one-pot, multi-component condensation reaction of hydrazine hydrate, carbon di-sulfide, 4-fluoro-benzyl chloride and isatin. The compound demonstrates near-planarity across much of the mol-ecule in the solid state and a configuration for the azomethine C=N bond. The form is further stabilized by the presence of an intra-molecular N-H⋯O hydrogen bond.

()-Benzyl 2-(5-methyl-2-oxoindolin-3-yl-idene)hydrazinecarbodi-thio-ate.

The title compound, CHNOS was obtained from the condensation reaction of -benzyl-dithio-carbazate and 5-methyl-isatin. In the solid-state, the mol-ecule adopts a configuration with the 5-methyl-isatin and di-thio-carbazate groups located on the same side of the C=N bond, involving an intra-molecular N-H⋯O hydrogen bond.

Methyl 4-amino-3-meth-oxy-isoxazole-5-carboxyl-ate.

The title compound, CHNO, a new derivative of isoxazole, has been synthesized and structurally characterized. The crystal structure shows the mol-ecule to be almost planar (r.m.

[3-Meth-oxy-5-(meth-oxy-carbon-yl)isoxazol-4-yl](4-meth-oxy-phen-yl)iodo-nium 2,2,2-tri-fluoro-acetate.

A new isoxazole-based iodo-noium salt, CHINO ·CFO , has been synthesized and structurally characterized. In the crystal, ions are linked by short I⋯O contacts to form a neutral tetra-ion aggregate. These combine with C-H⋯F and C-H⋯O inter-actions to form double-layered two-dimensional sheets in the (001) plane.

-Ethyl -(2,3,4)-4-hy-droxy-1,2-dimethyl-5-oxopyrrolidine-3-carboxyl-ate.

The asymmetric unit of the title compound, CHNO, consists of a functionalized pyrrolidine ring having an envelope conformation, synthesized as an ethyl ester. The mol-ecule has three chiral centres and crystallized as a racemic mixture. In the crystal, mol-ecules are linked by pairwise O-H⋯O bonds, generating dimers with twofold rotational symmetry.

The Synthesis and Evaluation of Fluoro-, Trifluoromethyl-, and Iodomuscimols as GABA Agonists.

Halogenated analogues of the neurotoxic alkaloid muscimol were prepared with fluorine, iodine or trifluoromethyl at the 4 position of the isoxazole ring system. These compounds were investigated as agonists for GABA receptors. Only the C-4 fluorine-containing analogue proved to be an active compound in these assays.