Ru-Morpholine-Derived Thiosemicarbazone-Based Metallodrugs: Lysosome-Targeted Anticancer Agents.

The idea of coordinating biologically active ligand systems to metal centers to exploit their synergistic effects has gained momentum. Therefore, in this report, three Ru complexes - of morpholine-derived thiosemicarbazone ligands have been prepared and characterized by spectroscopy and HRMS along with the structure of through a single-crystal X-ray diffraction study. The solution stability of - was tested using conventional techniques such as UV-vis and HRMS.

Compound risks of floods and droughts over multi-hazard catchments: Revealing association through hydrodynamic-cum-statistical modelling and novel bivariate risk classifier.

Floods and droughts are signature phases of the same hydrological cycle. Despite their profound impacts on the socio-economic structures and population globally, limited research efforts have encapsulated the resultant compound risks from them. Comprehending both water extremes presents a formidable challenge due to the relatively short-term occurrence of floods versus the prolonged impacts of droughts.

Optimizing pulmonary chest x-ray classification with stacked feature ensemble and swin transformer integration.

This research presents an integrated framework designed to automate the classification of pulmonary chest x-ray images. Leveraging convolutional neural networks (CNNs) with a focus on transformer architectures, the aim is to improve both the accuracy and efficiency of pulmonary chest x-ray image analysis. A central aspect of this approach involves utilizing pre-trained networks such as VGG16, ResNet50, and MobileNetV2 to create a feature ensemble.

A Schiff-Base Molecular Probe for Selective Fluorescence Sensing of Maleic Acid with Recognition of Maleic Acid in Food Additives and Cell Imaging.

The 2,4-dinitrophenylhydrazine based Schiff base (L) acts as an effective fluorescence sensor for the selective detection of maleic acid. The detection limit of L towards maleic acid is observed to be 1.29 × 10 M.

Survival Outcomes in US Medicare Patients with Non-Cystic Fibrosis Bronchiectasis by Rate of Baseline Exacerbations.

Introduction: There are limited real-world data on outcomes in patients with non-cystic fibrosis bronchiectasis (NCFBE). This study assessed clinical characteristics and survival in patients with NCFBE by baseline exacerbation rate.

Methods: Patients with bronchiectasis (≥ 1 inpatient or ≥ 2 outpatient claims with a bronchiectasis diagnosis code, or one outpatient claim with bronchiectasis code and a chest computed tomography scan) were from the 100% Medicare Fee-for-Service database (Jan 2014-Dec 2020).

Finding a balance: Reproductive trade-offs in parasitic isopods of the family Cymothoidae.

In this study conducted along the coast of Odisha, India, reproductive trade-offs in isopods of the family Cymothoidae were investigated, focusing on the relationship between the number vs. volume of eggs and the percentage of brood to body volume. Ovigerous females from species with substantial sample sizes (n > 30) were analyzed to understand their survival strategies.

An Unusual Presentation of Fatal Acute Haemorrhagic Pancreatitis in a Young Adult.

Acute haemorrhagic pancreatitis is a medical emergency and the most severe form of Acute Pancreatitis. It is characterized by severe epigastric pain that radiates to the back and is associated with vomiting. If not diagnosed and managed promptly, it may result in sudden, unexpected, unexplained deaths which fall within the medicolegal domain.

A comparative thermo-chemical characterization of oilseed, millet and pulse stem biomass for bioethanol production.

Various thermochemical and biochemical processes are resorted to transform agri-wastes into diverse green fuels. Current investigation encompassed three different types of biomass gingelly, kodo millet and horse grams, whose desirability as biofuel feedstock have been largely unexplored till date. The existence of significant amount of cellulose (38.

Risk of Glans Dehiscence Associated with Vascular Flap Coverage of the Glanular Neourethra during Primary Urethroplasty: A Randomised Controlled Trial.

Background: Hypospadias is one of the common congenital anomalies of male genitalia. Although over 300 different operative techniques have been described, post-operative complications are still common, of which glans dehiscence (GD) is the most severe complication requiring redo urethroplasty. Some surgeons use the vascular flap to cover the glanular part of the neourethra to prevent GD, but there are controversies regarding its usefulness.

Predictive Value of the Postural Difference in Antero-Posterior Diameter of Renal Pelvis on Ultrasonography of Unilateral Ureteropelvic Junction Obstruction in Determining the Need For Surgery.

Background: Ureteropelvic junction obstruction (UPJO) is the most common cause of antenatal hydronephrosis. Although majority of them improve with time, none of the existing diagnostic modalities can accurately predict which hydronephrotic kidney is at the risk of progressive renal damage and will benefit from early surgery. Postural variations in the anteroposterior pelvic diameter (APPD) of the hydronephrotic kidney in children during follow-up postnatal ultrasonography (USG) reflect the intrapelvic tension, which might help in predicting the need of surgery amongst these patients.

Discerning the dynamics of urbanization-climate change-flood risk nexus in densely populated urban mega cities: An appraisal of efficient flood management through spatiotemporal and geostatistical rainfall analysis and hydrodynamic modeling.

While the contribution of climate change towards intensifying urban flood risks is well acknowledged, the role of urbanization is less known. The present study, for the first time in flood management literature, explores whether and how unplanned-cum-urbanization may overshadow the contribution of extreme rainfall to flood impacts in densely populated urban regions. To establish this hypothesis and exemplify our proposed framework, the National Capital Territory (NCT) of Delhi in India, infamous for its concurrent flood episodes is selected.

Real-world treatment patterns, health care resource utilization, and costs in a US Medicare population with bronchiectasis.

Background: Bronchiectasis carries a significant economic burden with high health care expenditures associated with frequent hospitalizations, physician visits, and treatments, including oral and intravenous antibiotics for repeated lung infections, airway-clearance therapy, and oxygen administration. Bronchiectasis exacerbations can contribute to this burden.

Objective: To estimate US health care resource utilization (HCRU) and costs associated with bronchiectasis and with bronchiectasis exacerbations.

Inguinal Lipoblastoma Masquerading as Obstructed Omentocele in a Girl.

Lipoblastoma in the inguinal regional is a rare occurrence in children and can present as a surgical surprise during pediatric herniotomies. Irreducible inguinal hernia is one of the most common surgical problems dealt by pediatric surgery residents in emergency. We report a case of inguinal lipoblastoma presenting as irreducible groin swelling.

Pathogenic Role of Human Rhinovirus Mono-Infection in Pediatric Lower Respiratory Tract Infection.

Background and objective Human rhinovirus (HRV) is one of the leading causes of pediatric respiratory tract infection with a prevalence rate of 30-50%, mostly affecting children below five years of age and causing a substantial amount of economic loss. In children, it can alone or as a co-infection, cause a wide range of symptoms from mild to life-threatening ones. With the above background, the current study was carried out to emphasize the role of HRV mono-infection in pediatric acute respiratory tract infections by correlating clinical and molecular laboratory findings.

Pedestrian crash risk analysis using extreme value models: New insights and evidence.

Facilitating proactive pedestrian safety management, the application of extreme value theory (EVT) models has gained popularity due to its extrapolation capabilities of estimating crashes from their precursors (i.e., conflicts).

Can geomorphic flood descriptors coupled with machine learning models enhance in quantifying flood risks over data-scarce catchments? Development of a hybrid framework for Ganga basin (India).

Quantifying flood risks through a cascade of hydraulic-cum-hydrodynamic modelling is data-intensive and computationally demanding- a major constraint for economically struggling and data-scarce low and middle-income nations. Under such circumstances, geomorphic flood descriptors (GFDs), that encompass the hidden characteristics of flood propensity may assist in developing a nuanced understanding of flood risk management. In line with this, the present study proposes a novel framework for estimating flood hazard and population exposure by leveraging GFDs and Machine Learning (ML) models over severely flood-prone Ganga basin.

A Comprehensive Molecular, Biochemical, Histochemical, and Spectroscopic Characterization of Early and Medium Duration Rice Genotypes Investigating Dry Matter Accumulation Efficiencies.

Investigation on accumulation of cell wall components over critical growth stages will surely provide a new insight into dry matter accumulation studies in rice. An elevated biomass production provides an alternative strategy of yield improvement, which in turn maneuvers the species concerned as potential dual-purpose crop. On that note, present study was carried on 33 early and 39 medium duration rice genotypes.

Congenital Intraoral Dermoid and Epidermoid Cyst with Orocutaneous Fistula Presenting with Life-threatening Airway Obstruction in an Infant.

Dermoid cysts and epidermoid cysts in the floor of the mouth are rare in the pediatric age group. In this case report, we have discussed the presentation, management, and literature review of a 6-month-old female child presenting with both dermoid and epidermoid cysts in the floor of the mouth with an orocutaneous fistula.

Acute renal failure and hepatopathy consequent upon ingestion of cooked gallbladder of Indian carp: A case report.

Among freshwater fishes, the Indian Carp (, "ROHU") is one of the most chosen species for Indian diets, but reports of toxicity are rare. This report is of a middle-aged healthy female who developed pain in the abdomen, vomiting, and diarrhea within hours of ingestion of a cooked portion of Indian carp's intestines and gallbladder. There was an inadvertent delay in diagnosis over 1 week due to the rarity of incidence and non-availability of a definite diagnostic indicator coupled with the lack of awareness and high index of suspicion.