Publications by authors named "Mohana Ragu"
Breast cancer exhibits significant heterogeneity, manifesting in various subtypes that are critical in guiding treatment decisions. This study aimed to investigate the existence of distinct subtypes of breast cancer within the Asian population, by analysing the transcriptomic profiles of 934 breast cancer patients from a Malaysian cohort. Our findings reveal that the HR + /HER2- breast cancer samples display a distinct clustering pattern based on immune phenotypes, rather than conforming to the conventional luminal A-luminal B paradigm previously reported in breast cancers from women of European descent.
View Article and Find Full Text PDFBackground: Recent genomics studies of breast cancer in Asian cohorts have found a higher prevalence of TP53 mutations in Asian breast cancer patients relative to Caucasian patients. However, the effect of TP53 mutations on Asian breast tumours has not been comprehensively studied.
Methods: Here, we report an analysis of 492 breast cancer samples from the Malaysian Breast Cancer cohort where we examined the impact of TP53 somatic mutations in relation to PAM50 subtypes by comparing whole exome and transcriptome data from tumours with mutant and wild-type TP53.
Article Synopsis
- The production of allohexaploid Brassica (2n = AABBCC) has potential benefits for plant breeders, offering hybrid vigor and diverse genetic contributions from various Brassica genomes.
- High-throughput molecular techniques were employed to analyze a population of allohexaploid candidates, revealing that while allelic segregation generally adhered to Mendelian principles, there was no strong preference for complete 2n = AABBCC chromosome sets.
- Findings indicate that while there is potential for stable allohexaploid lines, effective selection for the desired chromosome configuration is crucial due to observed karyotype distortions in progeny.