Unveiling Myelodysplastic Syndromes: Exploring Pathogenic Mechanisms and Therapeutic Advances.

Myelodysplastic syndromes (MDSs), either primary or secondary, are a heterogeneous group of clonal hematological neoplasms characterized by bone marrow dyshematopoiesis, peripheral blood cytopenia, and the potential risk of acute myeloid leukemia (AML) transformation. The clinical heterogeneity in MDS is a reflection of the underlying multitude of genetic defects playing a role in the pathogenesis. Recent advances in the clinicopathological, immunophenotypic, and molecular landscape in understanding the pathophysiology of MDS lead to evolving and refined classification systems with newer entities.

Current State of Evidence on Definitions and Management of High-Risk Multiple Myeloma.

Purpose Of Review: This review aims to address the subgroup of patients with newly diagnosed multiple myeloma (NDMM) who have high-risk multiple myeloma (HRMM) and continue to experience poor outcomes despite recent therapeutic advances. We will explore various clinical, biochemical, imaging, genetic, and dynamic features associated with high-risk status, along with the different risk stratification tools developed to identify HRMM patients.

Recent Findings: Although numerous parameters for defining HRMM have been proposed, a universally accepted definition remains absent.

Safety and efficacy of CAR-T cell therapy in patients with autoimmune diseases: a systematic review.

Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the treatment of various hematological malignancies. Recently, CAR-T has been used in refractory auto-immune diseases with initial encouraging results. In this systematic review, we examined the safety and efficacy of CAR-T in patients with refractory auto-immune diseases.

Network pharmacology-integrated molecular modeling analysis of L. (agarwood) essential oil phytocompounds.

A network pharmacology approach was used to construct comprehensive pharmacological networks, elucidating the interactions between agarwood compounds and key biological targets associated with cancer pathways. We have employed a combination of network pharmacology, molecular docking and molecular dynamics to unravel agarwood plants' active components and potential mechanisms. Reported 23 molecules were collected from the agarwood plants and considered to identify molecular targets.

Transition from point A to volume based image guided brachytherapy across a network of centers in India through workshop and mentoring.

Aim: To demonstrate how workshop and mentoring across a network of radiotherapy centers helped in transitioning from point A to volume-based image guided brachytherapy in carcinoma cervix.

Materials And Methods: Based on discussion with different centers across the network, the lapses in cervical cancer treatment were identified and a workshop was designed to change the practice pattern. The main focus of the workshop was to streamline EBRT dose prescription protocols and implement volume based image guided brachytherapy through mentoring and hands on training.

Study of the upper airway anatomy using magnetic resonance imaging in Indian obese patients with obstructive sleep apnea - A pilot study.

Background: Obstructive sleep apnea (OSA) is very common in obese patients. However, why some obese patients have severe OSA while others do not is unclear. Research is limited regarding which structures contribute to upper airway narrowing, especially in Asian patients where bony restrictions is thought to be important.

Assessment of Bioactivity of Homalomena aromatica Essential Oil From Northeast India Through Combinative In Vitro and In Silico Approaches.

Homalomena aromatica Schott is a valuable medicinal aromatic plant having wide range of applications in ethnobotany, pharmacology, perfumery and flavor industry. Traditionally, various part of H. aromatica such as leaves and rhizomes were applied to treat joint pain, skin diseases, colds, asthma, diarrhea, and jaundice.

A comprehensive analysis of phytochemicals, antioxidant, anti-inflammatory, antibacterial, antifungal and phytoestrogenic properties of different parts of .

L., a medicinal plant rich in secondary metabolites, was studied for optimising bioactive compound extraction from various parts of the plant using ethanol-water (50:50), ethanol, and methanol solvents. Analysis of extracts for key phytochemicals like polyphenols, flavonoids, saponins, and alkaloids was performed using HPTLC, HPLC and gas chromatography.

Unique Pharmacological Properties and Safety Profiles of Loop Diuretics.

Loop diuretics are regarded as essential for the treatment of edematous conditions in heart failure, cirrhosis, and renal disease. The principal mechanism of action involves inhibiting the reabsorption of ions (Na+, 2Cl-, and K+) from the ascending loop of Henle. The pharmacokinetic (PK) and pharmacodynamic (PD) features of the commonly used diuretics (torsemide, furosemide, and bumetanide) influence the selection of diuretics in various disease states and dosing regimens.

Estimation of environment stability for fruit yield and capsaicin content by using two models in Jacq. (Ghost Pepper) with multi-year evaluation.

Background: Jacq. (Ghost Pepper) is well-known for its high pungency and pleasant aroma. The recent years witnessed a significant decline in popularity of this important crop due to the use of inferior planting material and lack of elite lines.

Extraction of kaempferol derivatives from and its diverse biological activities.

(Zygophyllaceae), is a plant commonly found in the desert region, well-known for its antioxidant, anticancer, wound healing, anti-inflammatory and antibacterial, properties. In this present work, we have studied the extraction of kaempferol derivatives from which showed excellent biological activities. The whole plant (root, leaves and stem) was extracted using ethanol, hydrolysed with HCl, and studied for the identification of active molecules.

MicroRNAs as promising biomarkers and potential therapeutic agents in breast cancer management: a comprehensive review.

Breast cancer (BC), a complex and varied ailment, poses a significant global health burden. MicroRNAs (miRNAs) have emerged as vital regulators in BC progression, with potential implications for diagnosis and treatment. This review aims to synthesize current insights into miRNA dysregulation in BC.

Isolation and identification of and its application in textile industries.

A light pink-coloured, rod-shaped, gram-negative bacterium isolated from an unproductive crude oil production area was considered as a sample for this study. The 16S rRNA gene sequence identified the isolate as . Comparing the standard colour measurement values set by the International Commission on Illumination (CIE) method confirms the colourant produced by the biomass of this microorganism as a 'light pink' colouration.

Frequency of heterotic hybrids in relation to general combining ability of parents in sweet corn.

The success of developing prominent hybrids directly depends on the selection of parents with good combining ability which can transfer desirable genes with additive effects to their progeny. The data of 42 hybrids generated using 7 × 7 full diallel design; their seven parents along with three check hybrids were subjected to combining ability analysis from the experiment that was carried out during rainy season 2019. The analysis of variance showed significant general combining ability, and specific combining ability mean sum of squares for all the thirteen characters studied.

Lutein/Zeaxanthin Isomers and Quercetagetin Combination Safeguards the Retina from Photo-Oxidative Damage by Modulating Neuroplasticity Markers and the Nrf2 Pathway.

Exposure to light-emitting diode (LED) light is a primary cause of retinal damage, resulting in vision loss. Several plant-derived substances, such as lutein and quercetagetin (QCG), show promise in supporting eye health. In this study, the impact of lutein/zeaxanthin (L/Z, Lutemax 2020) and QCG were evaluated individually and together in a rat model of LED-induced retinal damage.

Molecular genetic divergence analysis amongst high curcumin lines of Golden Crop (Curcuma longa L.) using SSR marker and use in trait-specific breeding.

Curcuma longa L., is recognized worldwide as a medicinally and economically important plant species due to its curcumin content which is an industrially important compound. In this study, a total of 329 accessions were collected from four states of India and planted in the experimental farm of CSIR-NEIST, Jorhat, India, in augmented design.

Optimizing hybrid vigor: a comprehensive analysis of genetic distance and heterosis in eggplant landraces.

Introduction: This study explored the molecular characterization of 14 eggplant (brinjal) genotypes to evaluate their genetic diversity and the impact of heterosis. As eggplant is a vital horticultural crop with substantial economic and nutritional value, a comprehensive understanding of its genetic makeup and heterosis effects is essential for effective breeding strategies. Our aim was not only to dissect the genetic diversity among these genotypes but also to determine how genetic distance impacts heterotic patterns, which could ultimately help improve hybrid breeding programs.

Assessment of selection criteria using multi-year study for effective breeding program of L.

Background: Ginger has been an important cash crop with numerous applications since ancient times. As the demand for ginger is ever-growing and being a seasonal crop, a high-yielding variety of ginger would be economically profitable.

Methods: In this study, 150 germplasm were collected from different regions of NE India and evaluated for three years in CRBD design with three replications.

Estimation of genetic variation in yield, its contributing characters and capsaicin content of Jacq. (ghost pepper) germplasm from Northeast India.

Jacq. (ghost pepper), a naturally occurring chili species of Northeast India is known throughout the world for its high pungency and a pleasant aroma. The economic importance is due to the high capsaicinoid levels, the main source for pharmaceutical industries.

Innovative study in renewable energy source through mixed surfactant system for eco-friendly environment.

Actual plan of research work was proposed for systematic investigating in the field of photogalvanic (PG) cells for solar energy transformation. It was necessary and proposed to carry out experimental work under the solar parameters for PG cells. The object of the research work is to enhance the solar energy conversion into electricity and store it through PG cells.

Stability estimation through multivariate approach among solasodine-rich lines of (C.B. Clarke): an important industrial plant.

is a medicinally important plant that is a source of steroidal alkaloids 'solasodine.' It has various industrial applications, including oral contraceptives and other pharmaceutical uses. The present study was based on 186 germplasm of , which were analyzed for the stability of economically important traits like solasodine content and fruit yield.