Introduction: Sickle cell disease has been associated with many renal structural and functional abnormalities. Collapsing glomerulopathy or the collapsing variant of focal segmental glomerulosclerosis is a rare clinicopathologic entity in patients with sickle cell disease that requires timely diagnosis and aggressive management.
Case Presentation: In this case report we describe a 21-year-old African-American woman with a medical history of significant sickle cell disease and asthma.