Role of diclofenac in reducing post-endoscopic retrograde cholangiopancreatography pancreatitis.

Background And Aims: Acute pancreatitis following endoscopic retrograde cholangiography presents a unique opportunity for prophylaxis and early modification of the disease process because the initial triggering event is temporally well defined and takes place in the hospital. We report a prospective, single-center, randomized, double-blind controlled trial to determine if rectal diclofenac reduces the incidence of pancreatitis following cholangiopancreatography.

Methods: Entry to the trial was restricted to patients who underwent endoscopic retrograde pancreatography.