Publications by authors named "Mohammed-Yehia El-Mir"
Cell Physiol Biochem
April 2012
Article Synopsis
- Glitazones, like pioglitazone and rosiglitazone, are insulin-sensitizing drugs that primarily act on a receptor called PPARγ, but they may also have other effects in the mitochondria that are not yet fully understood.
- In laboratory tests, these drugs were found to decrease oxygen consumption rates in liver cells and mitochondria, indicating a reduction in respiration and reactive oxygen species (ROS) production.
- The study revealed that these glitazones inhibit specific mitochondrial complexes (I and III), which could enhance their potential benefits in managing diabetes by reducing oxidative stress.
