Publications by authors named "Mohammed Yakasai Fatihu"
Effect of Zinc Supplementation on Altered Calcium Homeostasis, Parathyroid Gland, Bone, and Skeletal Muscle Histology Induced by Subchronic Oral Exposure to Glyphosate-Based Herbicide (GOBARA) in Wistar Rats.
Emmanuel Vandi Tizhe Ikechukwu Onyebuchi Igbokwe Celestine Onwu-Ibe Njokwu Mohammed Yakasai Fatihu Ussa Delia Tizhe
Clin Pathol
July 2024
Article Synopsis
- The study aimed to evaluate how zinc supplementation affects calcium balance and tissue health in rats exposed to glyphosate-based herbicide toxicity.
- Results showed that glyphosate exposure led to lower calcium and vitamin D levels, increased parathormone, and tissue damage in the parathyroid gland, bone, and muscle cells.
- Zinc pretreatment appeared to reduce these harmful effects, indicating a protective role against glyphosate-induced health issues.
Article Synopsis
- The study evaluated how zinc pretreatment affects liver and kidney damage in rats exposed to glyphosate-based herbicides over an extended period.
- After exposure to the herbicide, various serum markers indicated liver and kidney toxicity, with significant damage observed in organ tissues.
- Zinc pretreatment helped reduce some of the toxic effects in the blood, but it did not completely prevent the tissue damage associated with glyphosate exposure.
Influence of zinc supplementation on histopathological changes in the stomach, liver, kidney, brain, pancreas and spleen during subchronic exposure of Wistar rats to glyphosate.
Emmanuel Vandi Tizhe Najume Dogon-Giginya Ibrahim Mohammed Yakasai Fatihu Igbokwe Ikechukwu Onyebuchi Butcher Danladi Jonathan George
Comp Clin Path
October 2013
Article Synopsis
- A subchronic toxicity study investigated the effects of glyphosate on various organs in rats and the protective role of zinc when administered prior to glyphosate exposure.
- The study involved exposing rats to two doses of glyphosate for 8 weeks, leading to notable damage in organs like the stomach, liver, kidneys, brain, pancreas, and spleen, particularly at the higher dose of 375 mg/kg.
- Zinc supplementation significantly reduced the harmful histopathological changes caused by glyphosate, showing no alterations in the organ structure of zinc-supplemented rats, highlighting its potential protective effect.
A subchronic toxicity study was carried out to assess hepatic and renal functions of rats during oral exposure to glyphosate with zinc for the period of 8 weeks. Forty-eight Wistar rats used for the study were randomized into six groups of eight Wistar rats each, and each group had equal number of male and female Wistar rats. The Wistar rats administered with distilled water at 2 ml/kg body weight served as the control group (DW); others were administered with zinc at 50 mg/kg body weight (Z) group, glyphosate at 375 mg/kg body weight (G) group, a combination of zinc and glyphosate at 50 and 375 mg/kg body weight, respectively (Z + G), group, glyphosate at 14.
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