Bioactivity and molecular docking of lactones isolated from Czerep.

Two cytotoxic sesquiterpene lactones, 17-epichlorohyssopifolin A () and chlorjanerin (), and a monoterpene lactone, loliolide () were isolated from . The cytotoxicity of the total extract and terpenoids - were evaluated against three human cancer cells (HepG2, PC-3, and HT-29), along with the human normal primary epidermal keratinocytes (HEKa) cells. With IC values ranging between 0.