Disposition Kinetics of Cathinone and its Metabolites after Oral Administration in Rats.

Background: Cathinone is a natural stimulant found in the Catha edulis plant. Its derivatives make up the largest group of new psychoactive substances. In order to better understand its effects, it is imperative to investigate its distribution, pharmacokinetics, and metabolic profile.

Cathine and cathinone disposition kinetics and neurotransmitter profile in several organs of rats exposed to a single dose of extract.

Objectives: (Khat) is a stimulant plant that contains cathine and cathinone, which its abuses induce euphoria, alertness, and motor activity. Since the toxicokinetics of these substances remain unclear, this study was carried out to investigate the disposition kinetics of cathine and cathinone, the neurotransmitter profile, following a single dose of extract in rats.

Methods: Twenty-four adult male Wistar albino rats (250-300 g) were randomly selected and divided into six groups of four rats each.

Habitual khat chewing alters urinary inorganic profile in adult healthy males.

Objectives: Khat () is a stimulant plant, and it is abusive to induce euphoria, alertness and activity. Concomitant use of medications and khat chewing predisposes to the appearance of drug interactions result in treatment failure or toxicity. This study determined the changes in the urinary inorganic profile in adult healthy males who are chewing khat compared with non-khat chewer males.

Habitual khat chewing alters urinary inorganic profile in adult healthy males.

Objectives: Khat () is a stimulant plant, and it is abusive to induce euphoria, alertness and activity. Concomitant use of medications and khat chewing predisposes to the appearance of drug interactions result in treatment failure or toxicity. This study determined the changes in the urinary inorganic profile in adult healthy males who are chewing khat compared with non-khat chewer males.