Identification of genetic risk loci and causal insights associated with Parkinson's disease in African and African admixed populations: a genome-wide association study.

Background: An understanding of the genetic mechanisms underlying diseases in ancestrally diverse populations is an important step towards development of targeted treatments. Research in African and African admixed populations can enable mapping of complex traits, because of their genetic diversity, extensive population substructure, and distinct linkage disequilibrium patterns. We aimed to do a comprehensive genome-wide assessment in African and African admixed individuals to better understand the genetic architecture of Parkinson's disease in these underserved populations.

The effect of mobile phone utilization for enhanced adherence counselling intervention among persons with HIV.

The conduct of physical enhanced adherence counselling (EAC) for antiretroviral therapy (ART) non-adherers is often flawed by objectionable time lag from commencement to timely completion of the process. Therefore, we conducted a retrospective cohort study of 342 adults (≥18 years) with HIV on ART to determine the outcome of utilizing mobile phone based EAC intervention. Structural equation modelling framework, with full information maximum likelihood estimator was used to elucidate the pathways linking the relationship between individual characteristics, perceived barriers to ART adherence, and the applied interventions.

APOE E4 is associated with impaired self-declared cognition but not disease risk or age of onset in Nigerians with Parkinson's disease.

The relationship between APOE polymorphisms and Parkinson's disease (PD) in black Africans has not been previously investigated. We evaluated the association between APOE polymorphic variability and self-declared cognition in 1100 Nigerians with PD and 1097 age-matched healthy controls. Cognition in PD was assessed using the single item cognition question (item 1.

Assessment of cardiovascular risk factors in obese women with HIV.

Background: The risk of significant weight gain/obesity associated with recently adopted antiretroviral therapy (ART) has been shown to be particularly higher among the black race, and female gender compared to their male counterparts. Herein, we evaluated and compared subclinical CVD risk between apparently healthy obese (BMI ≥30 kg/m) and age matched normal BMI (BMI 18.5-24.

Double chambered left ventricle-institutional experience of two cases.

Background: Double Chambered Left Ventricle is a very rare congenital cardiac condition with limited cases reported in literature, etiology of which is obscure and presentation can be varied.

Aim Of The Study: To share our experience of two diverse cases of Double Chambered Left Ventricle at our institute.

Results: Two diverse cases of Double Chambered Left Ventricle were appropriately diagnosed and successfully managed.

Right pulmonary artery-Left atrium fistula: An institutional experience of seven cases over two decades.

Background: We report a series of 7 patients of right pulmonary artery to left atrium fistula operated in our institute between 1998 and 2019.

Aim Of The Study: To present a comprehensive management of right pulmonary artery to left atrium fistula in an organised manner with excellent results, even in adult population.

Methods: Seven consecutive patients of RPA to LA fistula were investigated with appropriate diagnostic modalities and underwent successful surgical correction.

A Cross-Sectional Comprehensive Assessment of the Profile and Burden of Non-motor Symptoms in Relation to Motor Phenotype in the Nigeria Parkinson Disease Registry Cohort.

Background: Data on non-motor symptoms (NMS) in black Africans with Parkinson's disease (PD) are sparse.

Objective: To describe the profile of NMS in the Nigeria PD Registry (NPDR) cohort and explore the relationship between NMS and PD motor phenotype.

Methods: We conducted a cross-sectional study of the frequency and burden of NMS, based on the non-motor symptoms scale (NMSS) and the Chaudhuri method respectively in our cohort.

The Nigeria Parkinson Disease Registry: Process, Profile, and Prospects of a Collaborative Project.

Background: Clinical disease registries are useful for quality improvement in care, benchmarking standards, and facilitating research. Collaborative networks established thence can enhance national and international studies by generating more robust samples and credible data and promote knowledge sharing and capacity building. This report describes the methodology, baseline data, and prospects of the Nigeria Parkinson Disease Registry.