No drains versus drains after perforated peptic ulcer repair: A randomized controlled trail.

Purpose: The study aimed to evaluate safety of omitting the intraabdominal drains after perforated peptic ulcer repairs.

Materials And Methods: We conducted a prospective, randomized, controlled trial from January 2022 to January 2024 at the Emergency surgery department. Patients with perforated peptic ulcers were evaluated for eligibility.

Intermediate Uveitis Complicated by Peripapillary Choroidal Neovascularization.

Choroidal neovascularization (CNV) is a very rare complication of intermediate uveitis with an incidence rate of around 2.0%. This case report examines the pathogenesis and prognosis of peripapillary CNV in a 52-year-old female patient with intermediate uveitis.

Mutations in NMNAT1 cause Leber congenital amaurosis and identify a new disease pathway for retinal degeneration.

Leber congenital amaurosis (LCA) is a blinding retinal disease that presents within the first year after birth. Using exome sequencing, we identified mutations in the nicotinamide adenine dinucleotide (NAD) synthase gene NMNAT1 encoding nicotinamide mononucleotide adenylyltransferase 1 in eight families with LCA, including the family in which LCA was originally linked to the LCA9 locus. Notably, all individuals with NMNAT1 mutations also have macular colobomas, which are severe degenerative entities of the central retina (fovea) devoid of tissue and photoreceptors.