Publications by authors named "Mohammed Mohieldien Abbas Elfaki"
Genetic Diversity and Population Genetic Structure Analysis of Thrombospondin-Related Apical Merozoite Protein (TRAMP) in Clinical Samples.
Md Atique Ahmed Rehan Haider Zaidi Gauspasha Yusuf Deshmukh Ahmed Saif Mohammed Abdulrahman Alshahrani Mohammed Mohieldien Abbas Elfaki
Genes (Basel)
October 2022
The simian malaria parasite causes a high number of zoonotic infections in Malaysia. The thrombospondin-related apical merozoite protein (TRAMP) is an essential ligand for binding to the erythrocyte cell surface, whereby it facilitates the invasion. This study is the first attempt to determine the genetic diversity, phylogeography, natural selection and population structure from 97 full-length gene sequences originating from Malaysia.
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- Plasmodium vivax is a major cause of malaria and poses challenges for vaccine development due to drug resistance and dormant liver forms.
- Researchers evaluated the PvRBP1a protein as a potential vaccine candidate, analyzing genetic diversity using clinical isolates from six countries which revealed extensive polymorphism in specific gene regions.
- Antigenicity testing indicated that the PvRBP1a-N region showed better sensitivity than PvRBP1a-C, identifying a promising target for vaccine development, but the presence of multiple genotypes and low overall antigenicity presents hurdles for creating an effective global vaccine.
Article Synopsis
- * The study analyzed blood samples from Sudan to investigate variations in the pvdbpII gene and the Duffy blood group, finding 20 single nucleotide polymorphisms (SNPs) and 11 distinct haplotypes among local P. vivax isolates.
- * Results indicated that the pvdbpII gene has undergone positive natural selection, which presents challenges for designing a universal vaccine based on DBP, due to the genetic diversity observed.