Publications by authors named "Mohammed Koudad"
Article Synopsis
- Two new chalcone-based imidazothiazole derivatives were synthesized and characterized using advanced techniques, confirming their structure through X-ray diffraction.
- The compounds demonstrated significant antiproliferative effects on various cancer cell lines (like MCF-7, A-549, and HT-29), while showing less effect on healthy 3T3-L1 cells, indicating a preference for cancerous over healthy cells.
- Studies revealed that these compounds induce apoptosis in cancer cells through mitochondrial disruption and caspase activation, with potential implications as effective anticancer drug candidates, supported by molecular docking studies and pharmacokinetic analysis.
Crystal structure of (5-methyl-imidazo[1,2-a]pyridin-2-yl)methanol.
Acta Crystallogr Sect E Struct Rep Online
November 2014
In the title compound, C9H10N2O, the imidazo[1,2-a]pyridine moiety is approximately planar (r.m.s.
View Article and Find Full Text PDF