Publications by authors named "Mohammed K Abdel-Hamid Amin"
Article Synopsis
- - The study focuses on the SARS-CoV-2 main protease enzyme (Mpro) as a key target for developing therapies against COVID-19, following the significant global impact of the pandemic.
- - Researchers utilized a computer-aided drug discovery process, which included designing a structure-based pharmacophore and filtering compounds from the ZINC chemical database, resulting in 703 potential candidates for Mpro inhibition.
- - The top candidate, compound W1 (ZINC000150656136), demonstrated strong binding properties and interactions with Mpro, with promising docking scores, suggesting it could be a lead compound for further experimental validation and clinical testing.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication depends on the interaction between the viral proteins and the human translation machinery. The cytotoxic peptide plitidepsin was found to inhibit CoV-2 up to 90 % at a concentration of 0.88 nM.
View Article and Find Full Text PDF