Publications by authors named "Mohammed Japer Mohammed Hakme"
Article Synopsis
- * There are seven triptans available, including Zolmitriptan and Sumatriptan, with Zolmitriptan now offered in various convenient forms like orally disintegrating tablets and nasal sprays.
- * The article discusses Zolmitriptan's pharmacological characteristics, including its tolerability, production, metabolism, and the challenges faced due to its first-pass degradation, as researchers seek innovative solutions.
One of the triazole tautomers, 1,2,4-triazole derivatives, has a wide range of biological activities that suggest its potential therapeutic utility in medicinal chemistry. These actions include anti-inflammatory, anti-cancer, anti-bacterial, anti-tuberculosis, and anti-diabetic effects. Using computational simulations and models, we investigate the structure-activity relationships of 1,2,4-triazoles, showing how various modifications to the triazole core yield a variety of clinical therapeutic benefits.
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