Publications by authors named "Mohammed Imaduddin Mirza"
Obesity is a major risk factor for cardiovascular disease. Blood-detected epigenetic profiles may serve as non-invasive clinically relevant biomarkers. Therefore, we investigated DNA methylation of genes involved in inflammation in peripheral blood of obese subjects and lean controls and their correlation with cardiometabolic measurements.
View Article and Find Full Text PDFArticle Synopsis
- High levels of homocysteine (Hcy) are common in obese individuals and are linked to increased cardiovascular risk, potentially due to low dietary folate and vitamin B12.
- The study examined how Hcy, folate, and vitamin B12 levels relate to vascular function in morbidly obese adults using advanced techniques to measure blood vessel dilation.
- Results showed that obese subjects had higher Hcy and lower folate, vitamin B12, and nitric oxide (NO) levels, indicating a strong connection between these factors and reduced blood vessel dilation capabilities, suggesting potential targets for improving vascular health in this group.