Upregulation of sulfatase-1 decreases metastatic potential of SKOV3 human ovarian cancer cells and .

Aim: Sulfatase-1 (SULF-1) is one of the genes associated with the inhibition of several signaling pathways by desulfating HSPG in cancer cells. The aim of this study is to investigate the effect of SULF-1 upregulation on SKOV3 ovarian cancer cell line and its influence on cell proliferation, migration, invasion in vitro, and lymph node metastasis in 615 inbred mice in vivo.

Materials And Methods: In in vitro study, we upregulated SULF-1 in SKOV3 cells using SULF-1 expression plasmid.