Upregulation of sulfatase-1 decreases metastatic potential of SKOV3 human ovarian cancer cells and .

Aim: Sulfatase-1 (SULF-1) is one of the genes associated with the inhibition of several signaling pathways by desulfating HSPG in cancer cells. The aim of this study is to investigate the effect of SULF-1 upregulation on SKOV3 ovarian cancer cell line and its influence on cell proliferation, migration, invasion in vitro, and lymph node metastasis in 615 inbred mice in vivo.

Materials And Methods: In in vitro study, we upregulated SULF-1 in SKOV3 cells using SULF-1 expression plasmid.

Cerebral venous thrombosis in Kuwait. Clinical presentation, risk factors, and management.

Objective: To explore the pattern of clinical presentations, risk factors, and the sinuses involved in cases of cerebral venous thrombosis (CVT) treated in a tertiary neurological center in Kuwait.

Methods: A retrospective analysis of cases of CVT treated at Ibn Sina Hospital, Kuwait, from January 2000 to October 2010. The records of 71 patients were retrieved and entered in a database.

Stent-assisted coil placement in a wide-necked persistent trigeminal artery aneurysm with jailing of the trigeminal artery: a case report.

We report the successful stent placement and secondary coil placement in a wide-necked persistent trigeminal artery (TA) aneurysm, in which the internal carotid artery (ICA) was preserved and the TA "jailed." Nine-month follow-up angiography revealed a completely obliterated aneurysm and patent parent ICA and TA. MR images obtained at 16-mo follow-up showed no infarction of the brain in the distribution of the jailed TA.