Modification of 4-(4-chlorothiophen-2-yl)thiazol-2-amine derivatives for the treatment of analgesia and inflammation: synthesis and , , and studies.

Inflammation is a protective response to a variety of infectious agents. To develop a new anti-inflammatory drug, we explored a pharmacologically important thiazole scaffold in this study. In a multi-step synthetic approach, we synthesized seven new thiazole derivatives (-).

Phenolic phytochemistry, , , , and mechanistic anti-inflammatory and antioxidant evaluations of .

Excessive and imbalance of free radicals within the body lead to inflammation. The objective of the current research work was to explore the anti-inflammatory and antioxidant potential of the isolated compounds from In this study, the isolated phenolic compounds were investigated for and anti-inflammatory potential along with the antioxidant enzyme. The anti-inflammatory and antioxidant potential of the phenolic compounds was assayed via various enzymes like COX-1/2, 5-LOX and ABTS, DPPH, and HO free radical enzyme inhibitory assay.

Sakuranetin ameliorates streptozotocin-induced diabetes in rodents by inhibiting caspase-3 activity, modulating hematological parameters, and suppressing inflammatory cytokines: a molecular docking and dynamics study.

Diabetes affects people of all ages, regardless of gender and background. To date, there is no evidence for the effect of sakuranetin against the streptozotocin (STZ)-induced diabetes paradigm. The research was directed to evaluate the antidiabetic activity of sakuranetin in the STZ model invoking the diabetes-induced disease paradigm.

Structure-Based In Silico Approaches Reveal IRESSA as a Multitargeted Breast Cancer Regulatory, Signalling, and Receptor Protein Inhibitor.

Breast cancer begins in the breast cells, mainly impacting women. It starts in the cells that line the milk ducts or lobules responsible for producing milk and can spread to nearby tissues and other body parts. In 2020, around 2.

Assessing Nutritional Anemia Among University Students in Jazan, Saudi Arabia: A Public Health Perspective.

Background: Nutritional anemia is a significant public health concern worldwide, particularly affecting young adults and children in Saudi Arabia, where inadequate nutrition is considered a primary contributing factor. This study aims to (i) examine the levels of serum iron, folate, and vitamin B in young adult students, with a focus on identifying any deficiencies and their association with anemia; (ii) explore the prevalence of mixed-deficiency anemia resulting from deficiencies in serum iron, folate, and vitamin B (iii) explore how sociodemographic characteristics and dietary habits influence serum iron, folate, and vitamin B levels.

Materials And Methods: This cross-sectional study encompassed 158 young adult students at Jazan University, Saudi Arabia.

Delineating Pixantrone Maleate's adroit activity against cervical cancer proteins through multitargeted docking-based MM\GBSA, QM-DFT and MD simulation.

Cervical cancer poses a substantial worldwide health challenge, especially in low- and middle-income nations, caused by high-risk types of human papillomavirus. It accounted for a significant percentage of cancer-related deaths among women, particularly in areas with limited healthcare resources, necessitating innovative therapeutic approaches, and single-targeted studies have produced significant results, with a considerable chance of developing resistance. Therefore, the multitargeted studies can work as a beacon of hope.

Gender Disparities in Osteoporosis Knowledge, Health Beliefs and Preventive Behaviors in Najran City, Saudi Arabia.

Osteoporosis is a chronic bone disease affecting both men and women, but it is more prevalent in women. Promoting a healthy lifestyle among adults, particularly women, is crucial in preventing and reducing the osteoporosis impact. This study aimed to compare the osteoporosis knowledge, health beliefs and preventive behaviors among adult male and female in Najran city Saudi Arabia.

Possible neglected transient (T) polyagglutination in critically ill patients with coronavirus disease-2019 (Covid-19).

T-activation polyagglutination can be caused by bacteria or viruses and has been associated with haemolytic anaemia. Coronavirus disease-19 (COVID-19) is also associated with haemolytic anaemia. The presented study aims to determine T activation polyagglutination in critically ill COVID-19 patients.

Determinant of Osteoporosis Preventive Behaviors among Perimenopausal Women: A Cross-Sectional Study to Explore the Role of Knowledge and Health Beliefs.

Osteoporosis is a silent chronic disease, and many people did not discover it until they were diagnosed with a fracture. Therefore, regular scanning and appropriate Osteoporosis Preventive Behaviors (OPB) are the management cornerstone. OPB is strongly affected by personal knowledge and health beliefs.

Persistence of hepatitis B surface antibody to hepatitis B vaccine among medical college students in Najran University, Saudi Arabia.

Around 257 to 291 million people worldwide are infected with the hepatitis B virus (HBV). Immunization is one of the most effective ways to combat HBV infection. Saudi Arabia implemented a mandatory hepatitis B immunization program in 1989.

In-Vitro, In-Vivo, Molecular Docking and ADMET Studies of 2-Substituted 3,7-Dihydroxy-4H-chromen-4-one for Oxidative Stress, Inflammation and Alzheimer's Disease.

Plants' bioactives are well-known safe drugs for vital diseases. Flavones and Flavonoid-rich dietary supplements are known to exhibit neuroprotective potential. In this study, we isolated a flavone 2-(3,4-dimethoxyphenyl)-3,7-dihydroxy-4H-chromen-4-one from and it was evaluated against various targets of the oxidative stress-related neurological disorders.

Prevalence and Correlation of Vitamin D Levels with Hematological and Biochemical Parameters in Young Adults.

Objective: Vitamin D has a pivotal role in maintaining healthy bones and in the modulation of multiple physiologic processes. Vitamin D deficiency has become a global burden that affects all members of society. This study aimed to investigate the prevalence and correlation of vitamin D deficiency with hematological and biochemical parameters in young adult college students.

Biological Evaluation, Phytochemical Screening, and Fabrication of Leaves Extract-Loaded Nanoparticles.

is a medicinally important plant, and by virtue of its rich phytochemical composition, this plant is widely used as essential component in traditional medication systems. Due to its wide range of medicinal applications, the extract-loaded chitosan (Ext+Ch), extract-loaded PEG (Ext+PEG), and extract-loaded locust bean gum (Ext+LGB) nanoparticles (NPs) were prepared in the present study. The prepared NPs were then evaluated for their antibacterial, antioxidant, and antidiabetic potentials.

Green Synthesis and Characterization of Iron Nanoparticles Synthesized from Aqueous Leaf Extract of and Its Biomedical Applications.

The cold extraction method was used to obtain the aqueous extract of leaves in a ratio of 1:10. Iron nanoparticles (FeNPs) were synthesized using aqueous leaf extract of as a reducing agent. The phytoreducing approach was used to make FeNPs by mixing 1 mL of plant extract with 1 mM of ferric sulfate.

Intention and self-efficacy for pap smear screening and Human Papilloma Virus vaccination among Saudi women at Najran city, KSA.

Exploring the women's intention of the core self-directed behaviors for cervical cancer prevention and their confident abilities for engagement is of utmost importance for targeted intervention development. This study investigates the Saudi women's intention and self-efficacy for Pap Smear Screening and HPV Vaccination in Najran city, KSA. It was a descriptive cross-sectional study incorporating a convenient sample of 1085 Saudi women through a social media-based four-part questionnaire: Basic Data and Reproductive Health History, Pap Smear Intention Scale, HPV vaccination intention scale, Self-Efficacy Scale for Pap smear testing, and HPV vaccination.

Impact of an educational intervention on deaf and hard hearing females' knowledge and health beliefs regarding cervical cancer in Tabuk, Saudi Arabia: A theory-based study.

Deaf people experience barriers to communication that prevent access to health care and information that puts them at increased risk for lack of knowledge about prevention and early detection approaches to cancers. With decreased screening, they may be at a higher risk of discovering cervical cancer (CC) at a late stage. This study aimed to evaluate the impact of an educational intervention on deaf and hard hearing females' knowledge and health belief regarding cervical cancer in Tabuk, Saudi Arabia.

Saudi women health beliefs and associated factors regarding cervical cancer prevention at Najran city: A theory-based study.

According to Saudi Arabia's 2030 vision, research should be directed to promote health and prevent diseases like cervical cancer (CC). Furthermore, the Kingdom pays specific attention to the health of women. CC ranks eighth among all cancers in Saudi Arabia; therefore, determining women's beliefs and associated factors will help prevent and treat them early.

Perceptions of barriers to cervical cancer screening among Saudi women: A cross-sectional study.

In the Kingdom of Saudi Arabia (KSA), Cervical Cancer (CC) ranked fourth in incidence and associated mortality among all cancers, with a mean age incidence of 61 years. This study evaluates the perceived barriers to CC screening among Saudi women in Najran city, KSA. A cross-sectional study was conducted in Najran/ KSA, involving 1085 females.

Predictors of cervical cancer knowledge and attitude among Saudi women in Najran city: A cross-sectional study.

This study explores the predictors of cervical cancer (CC) knowledge and attitude among Saudi women in Najran city. A descriptive cross-sectional study was conducted in Najran/ KSA to recruit 1085 participants from June to September 2021. An online self-reported questionnaire was used for data collection; it consisted of basic data and health history, a CC knowledge quiz, and a CC attitude scale.

Cervical cancer perceived risks and associated factors among women in Saudi Arabia: A cross-sectional study.

Examining the risk perception of one of the most life-threatening cancers among women, such as cervical cancer, will guide the development of targeted advocacy and educational programs to reduce the burden of the disease. The current study investigated cervical cancer perceived risks and associated factors among Saudi women. A cross-sectional study was conducted through a social media-based survey, which conveniently targeted 1085 Saudi women in Najran city.

Molecular Determination of Vascular Endothelial Growth Factor, miRNA-423 Gene Abnormalities by Utilizing ARMS-PCR and Their Association with Fetal Hemoglobin Expression in the Patients with Sickle Cell Disease.

Recent studies have indicated that microRNA and VEGF are considered to be genetic modifiers and are associated with elevated levels of fetal haemoglobin HbF, and thus they reduce the clinical impact of sickle haemoglobin (HbS) patients. This cross-sectional study was performed on clinical confirmed subjects of SCD cases. miR-423-rs6505162 C>T and VEGF-2578 C>A genotyping was conducted by ARMS-PCR in SCD and healthy controls.

Associated with Foodborne Infections of Animal Origins: Insights into Prevalence, Antimicrobial Resistance, Toxin Genes Profiles, and Toxinotypes.

Several food-poisoning outbreaks have been attributed to () worldwide. Despite that, this crisis was discussed in a few studies, and additional studies are urgently needed in this field. Therefore, we sought to highlight the prevalence, antimicrobial resistance, toxin profiles, and toxinotypes of isolates.

Preparation of Spice Extracts: Evaluation of Their Phytochemical, Antioxidant, Antityrosinase, and Anti--Glucosidase Properties Exploring Their Mechanism of Enzyme Inhibition with Antibrowning and Antidiabetic Studies .

Tyrosinase and -glucosidase enzymes are known as promising target candidates for inhibitors to control unwanted pigmentation and type II diabetics mellitus. Therefore, twenty extracts as enzyme inhibitors were prepared from edible spices: nutmeg, mace, star anise, fenugreek, and coriander aiming to explore their antioxidant, antibrowning, and antidiabetic potential. Results confirmed that all extracts showed potent antioxidant activity ranging from IC = 0.

Computational screening and biochemical analysis of and plants to find effective inhibitors against Receptor-Binding domain (RBD) of the spike protein of SARS-Cov-2.

Although World Health Organization-approved emergency vaccines are available in many countries, the mortality rate from COVID-19 remains high due to the fourth or fifth wave and the delta variant of the coronavirus. Thus, an effective mechanistic investigation in treating this disease is urgently needed. In this work, we extracted phytochemicals from two mangrove plants, and , assessing their potential actions against the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2.