The effect of preoperative hormonal stimulation on the urethral plate; A histologic and histochemical study.

Aim Of The Work: Preoperative hormone stimulation (PHS) is used to increase the glans size and may improve the cosmetic appearance after hypospadias surgery. The exact effect of PHS on different penile tissues remains unclear and controversial. Previous studies showed that PHS increased vessel density in the foreskin.

The relationship between DNA methyltransferase 3B (DNMT3B) and miR 124-3pa expressions in bladder cancer tissues.

Background: Cancer bladder is the most common malignant tumor affecting the urinary tract. Genetic alterations are tightly associated with the development of cancer bladder. MicroRNAs (miRNA) are small, noncoding single-stranded RNA molecules that have been linked to bladder cancer.

Hormone receptor expression in hypospadias.

Introduction: Sex hormone imbalance in utero is hypothesized to play an important role in the pathogenesis of hypospadias. Due to its easy accessibility, foreskin samples have been used to describe hormone receptor expression in rodents, and both adult and pediatric patients. In this study we conducted a systematic approach to assess hormone receptor expression in pediatric patients with hypospadias compared to healthy controls with a focus on age-matching and differences in severity and degree of hypospadias.

The urethral plate and the underlying tissue; a histological and histochemical study.

Objective: To examine the urethral plate and the underlying tissues in children with proximal hypospadias associated with severe chordee.

Materials And Methods: The urethral plate and the underlying tissue specimens were excised to correct severe chordee in 17 children with proximal and perineal hypospadias with severe chordee. The median age was 20 months (range 8-36).

Global Neuroblastoma Network: An international multidisciplinary neuroblastoma tumor board for resource-limited countries.

Background: Tumor boards are part of standard care of patients with complex cancers, but appropriate multidisciplinary expertise and infrastructure are often not available in low- and middle-income countries (LMIC) for pediatric cancers, such as neuroblastoma. Our goal was to review results of a Global Neuroblastoma Network (GNN) tumor board accessible to LMIC.

Methods: De-identified clinical cases presented via internet conference during a weekly GNN virtual tumor board from 2010 through 2020 were evaluated in a standardized format, including diagnostic imaging, pathology, therapy information, resource limitations, and questions for discussion.

Left Ventricular Remodeling Following Balloon Mitral Valvuloplasty in Rheumatic Mitral Stenosis: Magnetic Resonance Imaging Study.

Rheumatic heart disease affects primarily cardiac valves, it could involve the myocardium either primarily or secondary to heart valve affection. The influence of balloon mitral valvuloplasty (BMV) on left ventricular function has not been sufficiently studied. To determine the influence of balloon mitral valvuloplasty (BMV) on both global and regional left ventricular (LV) function.

Thermoelastic Processes by a Continuous Heat Source Line in an Infinite Solid via Moore-Gibson-Thompson Thermoelasticity.

Many attempts have been made to investigate the classical heat transfer of Fourier, and a number of improvements have been implemented. In this work, we consider a novel thermoelasticity model based on the Moore-Gibson-Thompson equation in cases where some of these models fail to be positive. This thermomechanical model has been constructed in combination with a hyperbolic partial differential equation for the variation of the displacement field and a parabolic differential equation for the temperature increment.

Lessons Learned from Large-Scale, First-Tier Clinical Exome Sequencing in a Highly Consanguineous Population.

We report the results of clinical exome sequencing (CES) on >2,200 previously unpublished Saudi families as a first-tier test. The predominance of autosomal-recessive causes allowed us to make several key observations. We highlight 155 genes that we propose to be recessive, disease-related candidates.

Safety and efficacy of quartz head contact laser ablation for large prostates using 980-nm laser: a comparative prospective study against that for small- and medium-sized prostates.

Objective: To examine the safety and efficacy of quartz head laser ablation of the prostate (QLAP) in the treatment of large and huge prostates as compared with small- and medium-sized ones.

Materials And Methods: Two hundred forty-two patients with lower urinary tract symptoms secondary to benign prostatic hypertrophy (BPH) were included in the study, of which 210 patients were evaluable. Patients were divided into 2 groups: group A: patients with BPH volume of <80 mL (120 patients) and group B patients with gland size ≥80 mL.