Publications by authors named "Mohammed El-Dosoky"
Differential Effect of Three Macrolide Antibiotics on Cardiac Pathology and Electrophysiology in a Myocardial Infarction Rat Model: Influence on Sodium Nav1.5 Channel Expression.
Pharmaceuticals (Basel)
June 2021
Macrolides were reported to have cardiotoxic effects presented mainly by electrocardiogram (ECG) changes with increased risk in cardiac patients. We aimed to determine the impact of three macrolides, azithromycin, clarithromycin and erythromycin, on cardiac electrophysiology, cardiac enzyme activities, histopathological changes, and sodium voltage-gated alpha subunit 5 (Nav1.5) channel expression.
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- A high-performance liquid chromatographic (HPLC) method has been developed to simultaneously measure elbasvir and grazoprevir, two FDA-approved drugs for hepatitis C treatment.
- The method utilizes a reversed phase BDS Hypersil C18 column with a mobile phase of acetonitrile and methanol, achieving a flow rate of 1 mL/min and UV detection at 253 nm.
- The method shows good linearity, accuracy, and precision for drug concentrations between 1-20 μg/mL and has been successfully applied to their pharmaceutical dosage forms.
Pulmonary disease is the most frequent and among the most severe extra-articular manifestation of rheumatoid arthritis (RA). However, this issue has not been sufficiently studied in Egyptian patients. The objectives of the present study are to investigate the prevalence and types of pulmonary involvement using high-resolution computed tomography scan (HRCT) and pulmonary function tests (PFT) and evaluate the association between respiratory symptoms and RA-lung disease in a group of Egyptian RA patients.
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