Publications by authors named "Mohammed Dawod"
Background: Brain metastases (BMs) in patients with extra-pulmonary neuroendocrine neoplasms (EP-NENs) are rare, and limited clinical information is available. The aim of this study was to detail the clinicopathological features, management and outcomes in patients with EP-NENs who developed BMs.
Methods: A retrospective single-centre analysis of consecutive patients with EP-NENs (August 2004-February 2020) was conducted.
Background: Management of pancreaticobiliary (PB) malignancies remains a clinical challenge. In this review, we focus on the management of oncological emergencies in PB malignancies and the potential complication of associated therapeutic interventions.
Methods: Biobliographic review of current evidence on the management of oncological emergencies, their potential complications, as well as synthesis of recommendations was performed.
Article Synopsis
- Neuroendocrine neoplasms (NENs) are complex cancers with increasing prevalence, requiring a multidisciplinary approach to treatment due to diverse outcomes based on factors like tumor grade and location.
- Large clinical trials have established important therapies for advanced small bowel neuroendocrine tumors (SBNETs), including somatostatin analogues and peptide receptor radionuclide therapy (PRRT), which have improved management strategies over the past decade.
- The review covers the current systemic treatment options for advanced SBNETs, highlights new therapies like tyrosine kinase inhibitors, and addresses ongoing questions and guideline recommendations for palliative care.
Approximately 1-2% of unselected patients with Non-small Cell Lung Cancer (NSCLC) harbor RET rearrangements resulting in enhanced cell survival and proliferation. The initial treatment strategy for RET rearranged NSCLC has been multi-target tyrosine kinase inhibition. With overall response rates (ORR) of 16-53% and a median progression-free survival (PFS) of 4.
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