Effect of Root Against MRSA and MDR- Biofilms on Excision Wound in Diabetic Mice: Comparative Study Between Methanolic Extract and Traditional Hydrophobic Preparation.

, commonly called dyer's alkanet (family-), is used traditionally in Saudi Arabia to treat skin infections. A methanolic extract and a traditional formulation of the root used in folklore were prepared. LC-MS analysis was conducted to identify probable compounds present in the extract and the traditional hydrophobic formulation.

A decade later: Assessing pregnant women's perspectives on non-invasive prenatal testing (NIPT) in Saudi Arabia.

Since its introduction a decade ago, non-invasive prenatal testing (NIPT) has been recognized as a highly accurate and safe screening option for expecting mothers, with its efficacy hinging on awareness, perceptions, and understanding of the test. We surveyed pregnant women in Saudi Arabia between December 2023 and February 2024 to assess the knowledge and acceptability of NIPT among them. A total of 212 pregnant women from various risk levels, socioeconomic statuses, and trimesters participated in the study, which was carried out at King Saud University Medical City (KSUMC) via online forms.

Antibacterial, Antibiofilm, and Wound Healing Activities of Rutin and Quercetin and Their Interaction with Gentamicin on Excision Wounds in Diabetic Mice.

Phytochemicals are effective and are gaining attention in fighting against drug-resistant bacterial strains. In the present study, rutin and quercetin were tested for antibacterial, antibiofilm, and wound healing activities on excision wounds infected with MDR- in diabetic mice. Antibacterial and antibiofilm activities were studied in vitro using broth dilution assay and crystal violet assay, respectively.

Intelligent Tutoring Systems, Generative Artificial Intelligence (AI), and Healthcare Agents: A Proof of Concept and Dual-Layer Approach.

This study introduces a novel methodology for enhancing intelligent tutoring systems (ITS) through the integration of generative artificial intelligence (GenAI) and specialized AI agents. We present a proof of concept (PoC) demo that implements a dual-layer GenAI validation approach that utilizes multiple large language models to ensure the reliability and pedagogical integrity of the AI-generated content. The system features role-specific AI agents, a GenAI-powered scoring mechanism, and an AI mentor that provides periodic guidance.

The impact of COVID-19 restrictions on crime and its implications for public health: a case study from a small developing country.

Background: Crime has been described as a public health issue in Trinidad and Tobago, a small developing nation. COVID-19 restrictions, aimed at maintaining public health safety by limiting disease spread, may have negatively impacted crime rates due to an alteration of social and economic conditions. This study evaluates the implications of these restrictions on crime dynamics and hence their impacts on overall public health.

Artificial intelligence in respiratory care: Current scenario and future perspective.

Background: This narrative review aims to explore the current state and future perspective of artificial intelligence (AI) in respiratory care. The objective is to provide insights into the potential impact of AI in this field.

Methods: A comprehensive analysis of relevant literature and research studies was conducted to examine the applications of AI in respiratory care and identify areas of advancement.

Assessment of the anti-cancer potential of leaf extract on MDA-MB-231, MCF-7, 4 T1, and MCF-10 breast cancer cell lines: Cytotoxic, apoptotic and oxidative assays.

is traditionally used to treat breast cancer in several Arab countries. Scientific studies have reported different effects of this plant on some cancer cell lines. The current study determined the anti-cancer potential of the methanolic extract of against four different types of breast cancer cell lines .

Gastroduodenal Tuberculosis Presenting as a Gastric Outlet Obstruction: A Case Report.

Abdominal tuberculosis (TB) can affect any part of the gastrointestinal tract, solid organs, peritoneum, or lymph nodes. The diagnosis of abdominal TB is usually delayed due to a lack of specific clinical signs and symptoms and the mimicking of other intra-abdominal diseases. We present a case of gastroduodenal tuberculosis with peripancreatic lymph node involvement presented as a gastric outlet obstruction that was treated conservatively with anti-tuberculosis medications.

Hypolipidemic and Antihyperlipidemic Effects of Methanolic Extract Is Mediated through Inhibition of Lipase Activity and Lipid Accumulation.

seeds are used in the treatment of various diseases, especially diabetes and associated complications, in different parts of the world. The present study was undertaken to determine the hypolipidemic and antihyperlipidemic effects of methanolic extract of seeds in rats. The extract was subjected to LC-MS analysis to determine the chemical constituents.

Effect of Extract on Excision Wound Biofilms of MRSA and in Diabetic Mice.

, a desert plant commonly known as yarrow, is traditionally used as an antimicrobial agent in folklore medicine in Saudi Arabia. The current study was undertaken to determine its antibiofilm activity against methicillin-resistant (MRSA) and multi-drug-resistant (MDR-) using in vitro and in vivo studies. A biofilm model induced through an excision wound in diabetic mice was used to evaluate its effect in vivo.

The antidiabetic effect of methanolic extract of seeds is mediated through multiple mechanisms of action.

is widely used in Indian and Chinese medicine in the treatment of diabetes. The current work determined the oral hypoglycemic and antidiabetic effects of seed extract in rats. The probable mechanism of action was evaluated by α - glucosidase inhibition, glucose metabolism in insulinoma (INS-1) cells to reflect secretion of insulin, and protein glycation inhibition.

A Simple In-Vivo Method for Evaluation of Antibiofilm and Wound Healing Activity Using Excision Wound Model in Diabetic Swiss Albino Mice.

The study developed a simple and inexpensive method to induce biofilm formation in-vivo for the evaluation of the antibiofilm activity of pharmacological agents using Swiss albino mice. Animals were made diabetic using streptozocin and nicotinamide. A cover slip containing preformed biofilm along with MRSA culture was introduced into the excision wound in these animals.

Antibacterial Activity of (Clove) Bud Oil and Its Interaction with Imipenem in Controlling Wound Infections in Rats Caused by Methicillin-Resistant .

Methicillin-resistant (MRSA) is one of the leading causes of infection worldwide. Clove oil's ability to inhibit the growth of MRSA was studied through in vitro and in vivo studies. The phytochemical components of clove oil were determined through gas chromatography-mass spectrometry (GC-MS) analysis.

and Antibacterial Effects of Frankincense Oil and Its Interaction with Some Antibiotics against Multidrug-Resistant Pathogens.

Frankincense ( oleo gum resin) is reported to possess antimicrobial activity against several pathogens in-vitro. The antimicrobial effects of frankincense oil and its interaction with imipenem and gentamicin against methicillin-resistant (MRSA) and multidrug-resistant were determined through in-vitro methods and an in-vivo study using a rat pneumonia model. Frankincense oil was subjected to GC-MS analysis to determine the different volatile components.

Beneficial Effect of Methanolic Extract of Frankincense () on Testis Mediated through Suppression of Oxidative Stress and Apoptosis.

oleo gum resin () commonly known as frankincense is traditionally used in many countries for its beneficial effect on male fertility. This study explores its effect on the male reproductive system after a 60-day repeated administration at two different doses to rats (in vivo) and on human Leydig cells (in vitro). The methanolic extract of was analyzed for the presence of various constituents by preliminary phytochemical analysis and gas chromatography-mass spectrometry (GC-MS) while quantitative analysis of boswellic acids was done by high-performance liquid chromatography (HPLC).

Effect of Leaf Extract on Excision Wound Infections in Rats: Antioxidant, Antimicrobial, and Gene Expression Analysis.

The present study investigated the wound healing activity of leaf extract on an infected excision wound model in rats. Infection was induced using methicillin-resistant (MRSA) or An investigation was also done to study the effect of extract on the vascular endothelial growth factor (VEGF) and transforming growth factor-beta 1 (TGF-β1) gene expression in vitro using human keratinocytes (HaCaT). The methanol extract of leaves was analyzed for the presence of phytochemicals by LCMS.

Frankincense extract protects against testicular damage through augmentation of antioxidant defense mechanisms and modulation of apoptotic genes expression.

Frankincense (Boswellia sacra Fluck.,) is traditionally used in the treatment of altered male fertile potential in several countries. This study evaluated the cytoprotective action of B.

Leaf Extract Promotes Healing of Infected Wounds in Diabetic Rats: Evidence of Antimicrobial, Antioxidant and Proliferative Properties.

is known to possess wound healing activity. The present study evaluated the healing properties of methanolic extract of leaves in excision wounds infected with methicillin-resistant (MRSA) or in diabetic rats. An in vitro study was also carried out to determine the gene expression of VEGF and TGF-β1.

The Potential Benefits of Using Garlic Oil and Its Active Constituent, Dially Disulphide, in Combination With Carvedilol in Ameliorating Isoprenaline-Induced Cardiac Damage in Rats.

Garlic oil and its primary component, diallyl disulphide (DADS), were tested in rats with isoprenaline (ISO) induced myocardial infarction for cardioprotective benefits when combined with carvedilol. Garlic oil (GO) was administered to rats (Sprague-dawley strain) at two doses of 50 and 100 mg/kg body weight, whereas DADS was given in two doses of 4.47 and 8.

Pharmacokinetic and pharmacodynamic interaction of Rosuvastatin calcium with guggulipid extract in rats.

Background & Objectives: Rosuvastatin calcium (RC) is a potent and competitive synthetic inhibitor of HMG-CoA reductase used for the treatment of dyslipidemia. Guggulipid obtained from is used in the treatment of a wide variety of diseases such as atherosclerosis, hypercholesterolemia, rheumatism, and obesity. The present study evaluates the pharmacokinetic and pharmacodynamic interactions between RC and the standardized guggulipid extract in rats.

A Case Control Study on Serum Levels of Potential Biomarkers in Male Breast Cancer Patients.

The global incidence of breast cancer among men is steadily growing. Despite this, compared to female breast cancer patients, there are very few studies on biomarkers in male breast cancer patients. A cross-sectional case control study was carried out to determine the serum levels of melatonin, ghrelin, dopamine, serotonin, epinephrine, and GABA in male breast cancer.

Haematotoxic effects of methanolic extract of oleo gum resin (frankinccense) in rats.

In several parts of the world, Fluck. is one of the most commonly used herbs for the treatment of arthritis. Its usage should be validated in light of recent findings of haematotoxicity.

COVID-19 and Psychological Health of Female Saudi Arabian Population: A Cross-Sectional Study.

The influence of the COVID-19 pandemic is unprecedented on physical and mental health. This study aimed to determine the impact of the COVID-19 event on mental health among Saudi Arabian females of Riyadh by a cross-sectional study design. The samples of the study were recruited using convenience and snowball sampling methods.

Role of in Enhancing Antiulcer Profile of Pantoprazole in Experimental Animals.

The carrot plant ) and its components are traditionally reported for the management of gastric ulcers. This study was performed to evaluate the role of carrot when administered concurrently with a conventional antiulcer treatment, pantoprazole, in alleviating gastric and duodenal ulcers in female experimental animals. The study involved standard animal models to determine the ulcer preventive effect using pylorus ligation, ethanol, and stress induced acute gastric ulcer models and duodenal ulcer models involving cysteamine.

Ultrasound-guided thrombin injection versus ultrasound-guided compression therapy of iatrogenic femoral false aneurysms: Single center experience.

Background: Iatrogenic femoral pseudoaneurysm (false aneurysm) due to arterial access following cardiovascular procedures is becoming common because of the increase in number and complexity of the procedures. Recently, percutaneous thrombin injection is becoming a popular treatment of these false aneurysms.The aim of this study was to assess the efficacy and safety of femoral pseudoaneurysm closure using ultrasound-guided thrombin injection in comparison to ultrasound-guided compression.