Exploring chaos and bifurcation in a discrete prey-predator based on coupled logistic map.

This research paper investigates discrete predator-prey dynamics with two logistic maps. The study extensively examines various aspects of the system's behavior. Firstly, it thoroughly investigates the existence and stability of fixed points within the system.

Qualitative analysis and phase of chaos control of the predator-prey model with Holling type-III.

In this study, we investigate the dynamics of a discrete-time with predator-prey system with a Holling-III type functional response model. The center manifold theorem and bifurcation theory are used to create existence conditions for flip bifurcations and Neimark-Sacker bifurcations. Bifurcation diagrams, maximum Lyapunov exponents, and phase portraits are examples of numerical simulations that not only show the soundness of theoretical analysis but also show complicated dynamical behaviors and biological processes.

Deciphering the Association of Cytokines, Chemokines, and Growth Factors in Chondrogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells Using an Osteochondral Culture System.

Osteoarthritis (OA) is a chronic degenerative joint disorder associated with degradation and decreased production of the extracellular matrix, eventually leading to cartilage destruction. Limited chondrocyte turnover, structural damage, and prevailing inflammatory milieu prevent efficient cartilage repair and restoration of joint function. In the present study, we evaluated the role of secreted cytokines, chemokines, and growth factors present in the culture supernatant obtained from an osteochondral model of cartilage differentiation using cartilage pellets (CP), bone marrow stem cells (BM-MSCs), and/or BM-MSCs + CP.

Combination of Mesenchymal Stem Cells, Cartilage Pellet and Bioscaffold Supported Cartilage Regeneration of a Full Thickness Articular Surface Defect in Rabbits.

Background: Mesenchymal stem cells (MSCs) and/or biological scaffolds have been used to regenerate articular cartilage with variable success. In the present study we evaluated cartilage regeneration using a combination of bone marrow (BM)-MSCs, Hyalofast and/or native cartilage tissue following full thickness surgical cartilage defect in rabbits.

Methods: Full-thickness surgical ablation of the medial-tibial cartilage was performed in New Zealand white (NZW) rabbits.

Derivation and differentiation of bone marrow mesenchymal stem cells from osteoarthritis patients.

Osteoarthritis (OA) of the knee is a degenerative joint disease caused by the progressive reduction of the articular cartilage surface that leads to reduced joint function. Cartilage degeneration occurs through gradual loss in extracellular matrix components including type II collagen and proteoglycan. Due to limited inherent self repair capacity of the cartilage, the use of cell-based therapies for articular cartilage regeneration is considered promising.

Identification of novel genetic variations affecting osteoarthritis patients.

Background: Osteoarthritis (OA) is a progressive joint disease characterized by gradual degradation of extracellular matrix (ECM) components in the cartilage and bone. The ECM of cartilage is a highly specified structure that is mainly composed of type II collagen and provides tensile strength to the tissue via aggrecan and proteoglycans. However, changes in the ECM composition and structure can lead to loss of collagen type II and network integrity.

Pelleted Bone Marrow Derived Mesenchymal Stem Cells Are Better Protected from the Deleterious Effects of Arthroscopic Heat Shock.

Introduction: The impact of arthroscopic temperature on joint tissues is poorly understood and it is not known how mesenchymal stem cells (MSCs) respond to the effects of heat generated by the device during the process of arthroscopy assisted experimental cell-based therapy. In the present study, we isolated and phenotypically characterized human bone marrow mesenchymal stem cells (hBMMSCs) from osteoarthritis (OA) patients, and evaluated the effect of arthroscopic heat on cells in suspension and pellet cultures.

Methods: Primary cultures of hBMMSCs were isolated from bone marrow aspirates of OA patients and cultured using DMEM supplemented with 10% FBS and characterized for their stemness.