Publications by authors named "Mohammed Al-Hunaini"
Background: Busulfan (Bu) is an alkylating drug used in many preparative regimens before hematopoietic stem cell transplantation (HSCT). It is conjugated in the liver mainly by glutathione S-transferase isoenzyme A1-1 ( GSTA1 ). Genetic polymorphisms in these isoenzymes may affect the pharmacokinetics of Bu and the clinical outcomes of HSCT.
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- * The study found that 96% of patients had to be hospitalized for related complications, with issues like infections and the need for blood transfusions being common.
- * Despite some serious cases including gestational hypertension and one death from postpartum hemorrhage, overall mortality was low, highlighting the need for further research to better understand these patients' conditions.