Publications by authors named "Mohammed Al-Azzani"

Article Synopsis
  • Parkinson's disease (PD) affects a small percentage of patients with a monogenic form linked to mutations in the alpha-synuclein (aSyn) gene, specifically missense variants that can cause familial PD.
  • A case study highlighted a patient with a novel heterozygous aSyn mutation (G14R) showing complex neurodegenerative symptoms and neuropathological findings typical of frontotemporal lobar degeneration.
  • Research on the G14R mutation indicated structural changes in aSyn, leading to increased inclusion formation and altered fibrillar morphologies, suggesting mechanisms for the observed disease characteristics.
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Background: Synucleinopathies are disorders characterized by the abnormal accumulation of α-synuclein (aSyn). Synaptic compromise is observed in synucleinopathies parallel to aSyn aggregation and is accompanied by transcript deregulation.

Objective: We sought to identify microRNAs associated with synaptic processes that may contribute to synaptic dysfunction and degeneration in synucleinopathies.

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Synucleinopathies are a group of neurodegenerative diseases, characterized by the abnormal accumulation of the protein alpha-synuclein (aSyn). aSyn is an intrinsically disordered protein that can adopt different aggregation states, some of which may be associated with disease. Therefore, understanding the transitions between such aggregation states may be essential for deciphering the molecular underpinnings underlying synucleinopathies.

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Parkinson's disease is a progressive neurodegenerative disorder characterized by the accumulation of misfolded alpha-synuclein in intraneuronal inclusions known as Lewy bodies and Lewy neurites. Multiple studies strongly implicate the levels of alpha-synuclein as a major risk factor for the onset and progression of Parkinson's disease. Alpha-synuclein pathology spreads progressively throughout interconnected brain regions but the precise molecular mechanisms underlying the seeding of alpha-synuclein aggregation are still unclear.

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Article Synopsis
  • * Sucrose is effective in reducing pain from single painful events in newborns, but its exact pain-relieving mechanism remains unclear; the study examined the role of the opioid system through the use of naltrexone.
  • * Findings reveal that combining naltrexone with sucrose not only alleviates pain sensitivity but also prevents impairment in long-term memory caused by neonatal pain, likely by normalizing levels of brain-derived neurotrophic factor (BDNF) and increasing β-endorphin levels in the brain.
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