Parametric optimization of flow in a solar chimney power plant under variable semi elliptical constraints.

In response to the ongoing quest for more efficient renewable energy sources, this research addresses a significant gap in understanding the performance variations of Solar Chimney Power Plant (SCPP) models, particularly focusing on the influence of flow parameters in full and half-inclined collector sections featuring semi-elliptical curvature. The motivation stems from the need to optimize SCPP designs for enhanced energy generation while minimizing resource utilization and environmental impact. This research focuses on investigating flow parameter variations in Solar Chimney Power Plant (SCPP) models with full and half-inclined collector sections featuring semi-elliptical curvature and variable semi-minor heights (b: 0.

A multimodal approach with firefly based CLAHE and multiscale fusion for enhancing underwater images.

With the advances in technology, humans tend to explore the world underwater in a more constructive way than before. The appearance of an underwater object varies depending on depth, biological composition, temperature, ocean currents, and other factors. This results in colour distorted images and hazy images with low contrast.

Targeted modification of furan-2-carboxaldehydes into Michael acceptor analogs yielded long-acting hemoglobin modulators with dual antisickling activities.

Sickle cell disease (SCD) is the most common genetic disorder, affecting millions of people worldwide. Aromatic aldehydes, which increase the oxygen affinity of human hemoglobin to prevent polymerization of sickle hemoglobin and inhibit red blood cell (RBC) sickling, have been the subject of keen interest for the development of effective treatment against SCD. However, the aldehyde functional group metabolic instability has severly hampered their development, except for voxelotor, which was approved in 2019 for SCD treatment.

Functional and structural properties of pyridoxal reductase (PdxI) from Escherichia coli: a pivotal enzyme in the vitamin B6 salvage pathway.

Pyridoxine 4-dehydrogenase (PdxI), a NADPH-dependent pyridoxal reductase, is one of the key players in the Escherichia coli pyridoxal 5'-phosphate (PLP) salvage pathway. This enzyme, which catalyses the reduction of pyridoxal into pyridoxine, causes pyridoxal to be converted into PLP via the formation of pyridoxine and pyridoxine phosphate. The structural and functional properties of PdxI were hitherto unknown, preventing a rational explanation of how and why this longer, detoured pathway occurs, given that, in E.

Analyzing Surface Roughness Variations in Material Extrusion Additive Manufacturing of Nylon Carbon Fiber Composites.

In recent years, fused deposition modeling (FDM) based on material extrusion additive manufacturing technology has become widely accepted as a cost-effective method for fabricating engineering components with net-shapes. However, the limited exploration of the influence of FDM process parameters on surface roughness parameters, i.e.

Estimating ground-level PM using subset regression model and machine learning algorithms in Asian megacity, Dhaka, Bangladesh.

Unlabelled: Fine particulate matter (PM) has become a prominent pollutant due to rapid economic development, urbanization, industrialization, and transport activities, which has serious adverse effects on human health and the environment. Many studies have employed traditional statistical models and remote-sensing technologies to estimate PM concentrations. However, statistical models have shown inconsistency in PM concentration predictions, while machine learning algorithms have excellent predictive capacity, but little research has been done on the complementary advantages of diverse approaches.

Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Aromatic Aldehydes as Drug Candidates for the Treatment of Sickle Cell Disease.

Sickle cell disease (SCD) is caused by a single-point mutation, and the ensuing deoxygenation-induced polymerization of sickle hemoglobin (HbS), and reduction in bioavailability of vascular nitric oxide (NO), contribute to the pathogenesis of the disease. In a proof-of-concept study, we successfully incorporated nitrate ester groups onto two previously studied potent antisickling aromatic aldehydes, TD7 and VZHE039, to form TD7-NO and VZHE039-NO hybrids, respectively. These compounds are stable in buffer but demonstrated the expected release of NO in whole blood in vitro and in mice.

Exploring the Application Sphere of the Internet of Things in Industry 4.0: A Review, Bibliometric and Content Analysis.

This paper aims to comprehensively review 891 documents in the Scopus database about Internet of Things (IoT) in Ind 4.0 to understand the historical growth, current state, and potential expansion trend. From 2014 to 2020, a systematic methodology gathered information on IoT in Ind 4.

In Vitro Antimycobacterial Activity and Physicochemical Characterization of Diaryl Ether Triclosan Analogues as Potential InhA Reductase Inhibitors.

Two sets of diphenyl ether derivatives incorporating five-membered 1,3,4-oxadiazoles, and their open-chain aryl hydrazone analogs were synthesized in good yields. Most of the synthesized compounds showed promising in vitro antimycobacterial activity against H37Rv. Three diphenyl ether derivatives, namely hydrazide , oxadiazole and naphthylarylidene exhibited pronounced activity with minimum inhibitory concentrations (MICs) of 0.

Design, synthesis and anticancer activity of novel valproic acid conjugates with improved histone deacetylase (HDAC) inhibitory activity.

Twenty-five valproic acid conjugates have been designed and synthesized. All target compounds were explored for their in vitro anti-proliferative activities using the MTT-based assay against four human cancer cell lines includingliver (HePG2), colon (HCT116), breast (MCF7) and cervical (HeLa) carcinoma cell lines. Out of six valproic acid-amino acid conjugates 2a-f.

Design, synthesis and biological evaluation of novel 5-((substituted quinolin-3-yl/1-naphthyl) methylene)-3-substituted imidazolidin-2,4-dione as HIV-1 fusion inhibitors.

A series of novel 5-(substituted quinolin-3-yl or 1-naphthyl)methylene)-3-substituted imidazolidin-2,4-dione 9-26 was designed and synthesized. The prepared compounds were identified using H NMR, C NMR as well as elemental analyses. The inhibitory activity of 9-26 on HIV-1 replication in MT-2 cells was evaluated.