Comparative immunohistochemical assessment of cutaneous cyclooxygenase-2 enzyme expression in chronological aging and photoaging.

Background/purpose: Skin aging can be classified into chronological aging and photoaging. Cyclooxygenase-2 (COX-2) may be involved in ultraviolet-induced inflammation, photocarcinogenesis and the aging process. Studies done focused on assessing COX-2 expression after acute ultraviolet exposure and in photocarcinogenesis.