Investigation of TLR2 (-196 to -174del) and TLR9 (T-1486C) Gene Polymorphisms Association with Inflammatory Bowel Diseases.

Background: Inflammatory bowel diseases (IBD), Crohn's disease (CD), and ulcerative colitis (UC) are diseases that result from the combined effects of a predisposing genetic background and several environmental factors, including smoking. Some genes can influence these diseases through genetic inheritance, and their regulation is explained by gene polymorphism. However, Toll-like receptor (TLR) genes have been identified as susceptibility genes for CD and UC.

Two new anticancer phenolic derivatives from leaves of Linn.

In this study, phytochemical analyses of the chloroform extract of L. var. and , Piperaceae, leaves led to the isolation of two new phenolic derivatives: 1--decanoyl hydroxy-benzoic acid/1--decanoyl phenol () and 3-phenol () on the basis of spectroscopic data 1D NMR (H, C) and 2D NMR (H - H COSY, HMBC) as well as ESI-MS, FT-IR and HR-ESI-MS analyses.