Publications by authors named "Mohammed A Mashali"
Article Synopsis
- Heart failure (HF) is a major clinical issue where current treatments primarily focus on symptom relief rather than halting disease progression.
- Research highlights the significance of calcium (Ca) regulation in innovative HF therapies, particularly its impact on heart function in different types of HF, such as HFpEF and HFrEF.
- Increased Ca sensitivity can improve heart contraction but may also increase risks for heart rhythm issues and sudden cardiac death, pointing to the need for targeted therapies that moderate Ca sensitivity to enhance treatment strategies for HF.
Article Synopsis
- The study investigates differences in contractile properties and mechanical synchrony between the left and right ventricles of healthy and failing human hearts.
- In nonfailing hearts, a strong correlation exists between the contractile performance of both ventricles, but this correlation weakens significantly in cases of end-stage heart failure.
- Findings indicate that the failing right ventricle shows altered contractile characteristics, leading to mechanical dyssynchrony compared to the left ventricle.
Background Because body mass index (BMI) is generally used clinically to define obesity and to estimate body adiposity, BMI likely is positively correlated with epicardial adipose tissue (EAT) level. Based on echocardiography, previous outcomes on this matter have varied from almost absent to rather strong correlations between BMI and EAT. The purpose of our study was to unambiguously examine EAT content and determine if correlations exist between EAT content and BMI, cause of heart failure, or contractile force.
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- Recent research has highlighted a growing interest in the link between hypothyroidism and heart failure (HF), particularly regarding how low T3 levels can predict mortality in HF patients.
- The study investigated the effect of hypothyroidism on the contractile properties of heart muscle by comparing samples from non-failing hearts and failing hearts with and without hypothyroidism.
- Results indicated that hypothyroidism did not significantly alter contractile properties in failing hearts, suggesting that advanced heart failure might overshadow any differences, warranting further investigation into hormone supplementation effects on heart performance.
Article Synopsis
- - Heart failure (HF) leads to serious health issues and high costs, yet even with advancements in treatment, outcomes remain poor; understanding cardiac muscle function during end-stage HF is essential for developing better therapies.
- - The study aimed to explore how different causes of HF (ischemic and non-ischemic) affect the force and contraction/relaxation kinetics in heart muscle, comparing both end-stage HF patients and those with non-failing hearts.
- - Results showed no major differences in baseline contractile force among groups, but the kinetics of relaxation were significantly slower in non-ischemic failing hearts compared to non-failing hearts, and both HF types showed impaired responses to frequency changes and β-adrenergic stimulation.