Publications by authors named "Mohammed A Alsaegh"
Article Synopsis
- The study assessed the integrity of non-sterile, powder-free latex gloves used by dental students across various specialties, finding a high rate of perforations (40.7%).
- The gloves were analyzed using a modified water leak test after use in procedures like operative dentistry and oral surgery, revealing significant perforations mainly at the right thumb and index finger.
- No statistical differences were found based on the type of dental procedure or duration of glove use, but there was a notable correlation between expected and actual defects in glove integrity.
The removal of lower third molars is one of the most common surgical procedures in routine dental practice. However, perforation of the mandibular third molars by the inferior alveolar nerve (IAN) is a rare occurrence. These cases are considered to carry a heightened risk of IAN injury due to the nerve being entrapped within the tooth.
View Article and Find Full Text PDFObjectives: This study aimed to evaluate the expression levels of hypoxia-inducible factor 1-α (HIF-1α) and vascular endothelial growth factor (VEGF) in radicular cysts and periapical granulomas, thereby contributing to the understanding of their potential significance in the differential diagnosis and treatment of these lesions.
Materials And Methods: In the present cross-sectional study, 51 samples of periapical lesions were included. Of them, 24 samples were radicular cysts, and 27 samples were periapical granulomas.
Article Synopsis
- Periodontitis is linked to chronic inflammation and pro-inflammatory markers like MIP-1α and CRP, which are significant in assessing inflammation in heart disease.
- This study evaluates biomarker levels in three groups: healthy individuals, those with stage III periodontitis, and post-myocardial infarction patients with stage III periodontitis.
- Results show that periodontitis patients have lower adiponectin and higher CRP and MIP-1α levels, suggesting a potential risk for cardiovascular events, highlighting the need for early detection and treatment of periodontitis.
Purpose: This study investigated the levels of salivary proinflammatory cytokines in the saliva of patients living with type II diabetes mellitus (DM) compared to those in healthy individuals three times: before tooth extraction and at 2 hours and 2 days after tooth extraction.
Methods: The study included 27 participants. Among them, 20 (n = 20; 74%) had type II DM, and seven (n = 7; 26%) were healthy control subjects.
Objectives: The aim of the current study was to identify the expression of P63 and its relation to odontogenic epithelial cell proliferation, severity of the inflammatory infiltrate and size of radicular cysts (RCs).
Methods: In this retrospective cross-sectional study, 30 cases of paraffin-embedded RCs were randomly selected from the archive. P63 and Ki-67 expression was assessed by immunohistochemistry.
Recently, 1-nonadecene and L-lactic acid were identified as unique metabolites in radicular cysts and periapical granuloma, respectively. However, the biological roles of these metabolites were unknown. Therefore, we aimed to investigate the inflammatory and mesenchymal-epithelial transition (MET) effects of 1-nonadecene, and the inflammatory and collagen precipitation effects of L-lactic acid on both periodontal ligament fibroblasts (PdLFs) and peripheral blood mononuclear cells (PBMCs).
View Article and Find Full Text PDFAims: This study aimed at evaluating the ability to feel bone touch, positive aspirations, and frequency of the success rate during the direct inferior alveolar nerve block (IANB) among dental students.
Methods: This prospective cross-sectional study involved 203 cases of IANB injections for patients requiring extraction of mandibular posterior teeth who visited student dental clinics at Ajman University, Fujairah Campus. Students' performance of direct IANB including ability to perceive bone touch, frequency of positive aspirations, and success rate were reported.
Objectives: Odontogenic lesions evolve as a result of altered dental development. This study aimed to evaluate the prevalence and the coinfection of Epstein-Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV) in radicular cysts, dentigerous cysts, odontogenic keratocysts, and ameloblastomas.
Methods: Polymerase chain reaction (PCR) was used to analyse 66 cases of odontogenic lesions for the presence of EBV-DNA and KSHV-DNA.
Article Synopsis
- The study aimed to analyze how mandibular third molars (MTMs) become impacted and their link to dental caries in neighboring mandibular second molars (MSMs) in Emirati patients.
- A review of 2000 dental X-rays found that 23.05% of patients had at least one impacted MTM, with the most common type being mesioangular, level B, and class II impactions.
- It was revealed that these types of impactions were more likely to cause carious lesions in adjacent MSMs, and that females had a higher occurrence of level C impactions, making surgical removal potentially more difficult for them compared to males.
Objectives: Particle size and shape can influence the properties of materials. However, to improve the physicochemical and biological properties of mineral trioxide aggregate (MTA), silicate-based hydraulic cements were introduced. This study aimed to evaluate and compare the major constituents and crystalline structures along with the surface morphology of different types of calcium silicate-based cement (CSC).
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- This study aimed to evaluate how common unculturable bacteria are in dental issues like periapical abscesses, radicular cysts, and periapical granulomas.
- Researchers systematically analyzed 13 studies over a span of 30 years to find that around 13% of bacteria in abscesses were unculturable, with variations based on the country.
- The findings suggest that unculturable bacteria could be important in the development of these dental conditions, though their exact role remains uncertain.
The role of inflammatory mediators in dental pulp is unique. The local environment of pulp responds to any changes in the physiology that are highly fundamental, like odontoblast cell differentiation and other secretory activity. The aim of this review is to assess the role of cathelicidins based on their capacity to heal wounds, their immunomodulatory potential, and their ability to stimulate cytokine production and stimulate immune-inflammatory response in pulp and periapex.
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- The study investigates the presence of human cytomegalovirus (HCMV) in various odontogenic cysts and tumors, specifically dentigerous cysts (DC), odontogenic keratocysts (OKC), and ameloblastomas (AB).
- HCMV-DNA and glycoprotein B (gB) detection revealed a higher prevalence in ameloblastoma samples, suggesting a potential link between the virus and tumor development.
- The study recommends using immunohistochemistry (IHC) for improved detection of HCMV in odontogenic tumors, particularly in ameloblastoma.
Article Synopsis
- The study investigates the expression of p63 protein in three types of odontogenic lesions: dentigerous cysts (DC), odontogenic keratocysts (OKC), and ameloblastomas (AB) to improve understanding of these cysts and tumors.
- Statistical analysis indicated a significant difference in p63 expression, with higher levels found in OKC compared to DC, suggesting distinct biological behaviors among these lesions.
- The results also showed a positive correlation between p63 and Ki-67 (a proliferation marker) in both DC and OKC, but not in AB, highlighting different roles of p63 in various odontogenic conditions.
Article Synopsis
- The study investigates the expression of Keratin 15 (K15) in various odontogenic lesions, namely dentigerous cysts, odontogenic keratocysts, and ameloblastomas.
- The research included 41 samples, using immunohistochemistry to analyze K15 expression, which was found to be present in most lesions without significant differences among them.
- The findings suggest that while K15 shows high expression in these lesions, it may not serve as a reliable stem cell marker, but could indicate abnormal differentiation in the epithelial cells of the lesions.
Investigation of cyclooxygenase (COX)-2 in dentigerous cyst and ameloblastoma may help to improve understanding of the nature and behavior of odontogenic cysts and tumors, and in addition may eventually represent a definitive target for a pharmacological approach in the management of these lesions. The aim of this study was to evaluate COX-2 expression and its correlation with the proliferation of odontogenic epithelium in these lesions. Dentigerous cysts (n=16) and ameloblastomas (n=17) were evaluated.
View Article and Find Full Text PDFThe aim of the current study was to investigate the presence of human papillomavirus (HPV) and evaluate its association with Ki-67 and cyclooxygenase-2 (COX-2) expressions in keratocystic odontogenic tumor (KCOT). Nineteen cases were included in the present study. Conventional PCR method and immunohistochemical analysis were performed for the detection of HPV-DNA and HPV-L1 capsid protein.
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