Publications by authors named "Mohammadreza Shafiei"

Article Synopsis
  • - Human T-lymphotropic virus (HTLV-1) affects over 10 million people worldwide and is associated with two main diseases: Adult T cell Leukemia-Lymphoma (ATLL) and HTLV-1-associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP).
  • - A systematic review analyzed 20 studies involving 1,420 cases and found that IL-17 cytokine levels were higher in HAM/TSP patients but reduced in those with ATLL.
  • - The findings suggest that enhancing the RORC/IL-17 signaling pathway may help ATLL patients, while anti-IL-17 therapies could improve outcomes for those suffering from HAM/TSP and other HTLV
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Article Synopsis
  • Viruses constantly challenge human health, requiring the immune system to develop strong defenses, particularly through natural killer (NK) cells that help detect and eliminate infected cells.* -
  • NK cells are essential for early antiviral responses but undergo significant changes during infections that can affect their functionality and effectiveness.* -
  • This review focuses on the dual role of NK cells in antiviral immunity and their transformation during viral encounters, providing insights that could lead to new therapeutic strategies against viral diseases.*
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Backgroud: Because of the important role of adhering to treatment to reduce major adverse cardiovascular events and mortality, studying the factors affecting treatment adherence (TA) is warranted. This study aimed to identify the impact of psychosomatic factors on adhering to treatment among patients with acute myocardial infarction.

Materials And Methods: This is a cohort study as a part of the Isfahan ST-segment-elevated Myocardial Infarction Cohort Study.

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Purpose: We present a patient with CARD9 deficiency and allergic bronchopulmonary aspergillosis (ABPA)-like presentation.

Methods: Following medical history taking and routine laboratory investigations, an inborn error of immunity was suspected, and the responsible variant was identified using Whole Exome Sequencing and confirmed by Sanger sequencing.

Results: A 14-year-old Iranian female presented with a history of chest pain, productive cough, dyspnea, malaise, and recurrent fever.

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Background: This study aimed to investigate readmission risk factors after ST-elevation myocardial infarction (STEMI) during a 3-year follow-up.

Methods: This study is a secondary analysis of the STEMI Cohort Study (SEMI-CI) in Isfahan, Iran, with 867 patients. A trained nurse gathered the demographic, medical history, laboratory, and clinical data at discharge.

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Human T lymphotropic virus-associated myelopathy/tropical spastic paraparesis (HTLV/TSP), also known as HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP), and multiple sclerosis (MS) are chronic debilitating diseases of the central nervous system; although the etiology of which is different, similarities have been observed between these two demyelinating diseases, especially in clinical manifestation and immunopathogenesis. Exorbitant response of the immune system to the virus and neurons in CNS is the causative agent of HAM/TSP and MS, respectively. Helper T lymphocyte-17 cells (Th17s), a component of the immune system, which have a proven role in immunity and autoimmunity, mediate protection against bacterial/fungal infections.

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Background: The Isfahan COVID Cohort (ICC) study was designed to investigate the short- and long-term consequences of patients with COVID-19 in Iran. This report presents the rationale, methodology, and initial results of ICC.

Materials And Methods: ICC is a 5-year multicentric prospective cohort study that is ongoing on two groups including 5000 patients hospitalized with moderate or severe and 800 nonhospitalized patients with mild or asymptomatic COVID-19 in Isfahan.

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The study aimed to determine different lifestyle and clinical factors that predict self-rated health (SRH) in non-cardiac chest pain (NCCP) patients. In this cross-sectional study, 360 NCCP patients filled out questionnaires about depression, somatization, body sensation, type D personality, and pain intensity. In addition, participants' lifestyle and socio-demographic data were obtained.

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