Assessment of Insulin, GLUT2 and inflammatory cytokines genes expression in pancreatic -Cells in zebrafish ( with overfeeding diabetes induction w/o glucose.

Abstract: In recent years, zebrafish have been proposed as a model for rapid analysis of gene function and biological activity due to high genetic similarities with humans. The aim of this study was to determine the effects of overfeeding-induced diabetes w/o glucose on inflammatory cytokine as well as insulin and glucose transporter-2 genes (GLUT2) genes expression in the pancreas in zebrafish.

Materials And Methods: The experiment was performed on 120 zebrafish (duplicated sample) with a specific genetic mapping (AB-Wild type).