Publications by authors named "Mohammadamin Parsaei"

Article Synopsis
  • - The study found that 38.7% of hospitalized patients in Iran reported mental distress, with a higher prevalence in males (52.0%) compared to females (34.0%) and significant variations based on job status and hospital wards.
  • - Data was collected using the General Health Questionnaire-12 (GHQ-12), with scores of 4 or higher designated as "mentally distressed," revealing that retired patients faced the highest rates of distress at 64.7%.
  • - The results emphasize the necessity for combining mental health evaluations with medical care to enhance treatment outcomes and quality of life for hospitalized patients experiencing mental distress.
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Background: While the link between body growth indices in the first three years of life and neurodevelopment is well established, the relationship between these indicators and intelligence levels in later stages is not well understood. This study aimed to investigate the association between various anthropometric indices and Intelligence Quotient in early school-aged children.

Methods: This cross-sectional study recruited healthy students aged 7 to 8 years from four primary schools in Tehran, Iran.

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Background: Traumatic brain injury (TBI) is a major cause of global mortality and disability, leading to primary and secondary brain injuries that can result in severe neurological, cognitive, and psychological impairments. Accurate and early prognosis of TBI outcomes is critical, particularly in assessing the risk of neurological decline, intracranial pressure (ICP) changes, and mortality.

Objective: This systematic review aims to evaluate the prognostic value of quantitative pupillometry, particularly the Neurological Pupil Index (NPi), in predicting long-term outcomes in TBI patients.

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Article Synopsis
  • Gestational diabetes mellitus is common and affects maternal and neonatal health, making it important to find reliable biomarkers for prediction and diagnosis, particularly in patients with intrahepatic cholestasis of pregnancy.* -
  • A systematic search and meta-analysis of 15 studies revealed higher serum total bile acid levels in women with gestational diabetes compared to controls, especially when levels were measured earlier in pregnancy before diagnosis.* -
  • The analysis showed no significant difference in total bile acid levels after gestational diabetes was diagnosed, indicating that earlier measurements might be more predictive of the condition.*
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Introduction: Optical coherence tomography angiography (OCTA) is an emerging technique to investigate retinal and choroidal microvascular alterations in patients with systemic sclerosis (SSc). This systematic review and meta-analysis aimed to evaluate the features of retinal and choroidal microvasculature using OCTA among SSc patients.

Methods: The methodology of the study was based on PRISMA guidelines.

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Objective: To compare residual myometrial thickness (RMT) and cesarean scar defect (CSD) development after cesarean section using double-layer locked and unlocked closure techniques.

Materials And Methods: We conducted a randomized double-blinded trial comparing double-layer locked and unlocked uterine closure techniques following cesarean section in primiparous women. The locked technique involved continuous suturing of the full myometrial thickness in the first layer, followed by back-and-forth needle maneuvering on both sides of the incision for the second layer.

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Aim: To explore white matter (WM) tracts linked to impulsivity using the diffusion magnetic resonance imaging (DMRI) connectometry method.

Methods: We analyzed 218 healthy participants from the Leipzig Study for Mind-Body-Emotion Interactions database. Impulsivity correlations with DMRI-derived WM changes were assessed using Urgency-Premeditation-Perseverance-Sensation (UPPS) Impulsive Behavior Scale subscales: lack of perseverance (PE), lack of premeditation (PM), sensation seeking (SS), and negative urgency.

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Olfactory dysfunction (OD) is a non-motor symptom of Parkinson's Disease, affecting 75-95% of the patients. This symptom usually emerges before the clinical diagnosis, and patients with OD present with more severe forms of PD and need higher doses of therapy. It remains unknown whether OD is just a mere non-motor symptom or if it is a part of a series of pathological changes in different brain regions of the affected patients.

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Background: An enduring challenge for women diagnosed with Turner syndrome (TS) is infertility. Oocyte donation (OD) offers a chance of pregnancy for these patients. However, current data on pregnancy outcomes are inadequate.

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Background: The optimal approach to luteal-phase support in infertility treatment remains a subject of debate. This study was conducted to investigate the clinical outcomes, side effects, and patient satisfaction associated with vaginal, subcutaneous, and intramuscular progesterone administration in infertile women undergoing Frozen Embryo Transfer (FET).

Methods: This three-armed randomized clinical trial assigned infertile patients eligible for FET to three progesterone treatment groups: vaginal suppositories (400 mg twice daily; n = 100), subcutaneous injections (25 mg daily; n = 102), and intramuscular injections (50 mg daily; n = 108).

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Article Synopsis
  • The study investigates the relationship between cognitive functions and the brain's white matter structure using advanced imaging techniques, specifically Diffusion Magnetic Resonance Imaging (DMRI).
  • Researchers analyzed data from 125 healthy participants, correlating white matter integrity (measured via Quantitative Anisotropy) with scores on various cognitive tests assessing attention, executive function, episodic memory, and working memory.
  • Significant correlations were found, indicating that the integrity of specific white matter tracts is closely linked to cognitive performance, which could aid in the early detection and intervention for cognitive disorders.
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Purpose: Colorectal cancer is the second leading cause of cancer death worldwide. Standard treatments for locally advanced rectal cancer include neoadjuvant chemoradiotherapy and total mesorectal excision (TME), which are associated with significant morbidity. After neoadjuvant therapy, one-third of patients achieve a pathological complete response (pCR) and are eligible for a watch-and-wait approach without TME.

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Problem: Achieving pregnancy through in vitro fertilization (IVF) remains a challenge, with less than one-third of women succeeding. There is a pressing need for reliable predictive tools to assess the likelihood of post-IVF pregnancy. While some serum inflammatory biomarkers have been investigated for their predictive potential, substantial knowledge gaps persist.

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Maternal obesity before or during pregnancy has been associated previously in offspring with a wide range of poor neurodevelopmental outcomes and mental health problems. The effects of maternal obesity on offspring brain structure and function that may be responsible for these poor outcomes are not well understood. We, therefore, undertook a systematic review of magnetic resonance imaging (MRI) studies that have assessed the associations of maternal obesity with brain measures in offspring.

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Article Synopsis
  • Digital Polymerase Chain Reaction (dPCR) is a highly efficient method for quantifying DNA and identifying copy number variants, particularly useful in non-invasive prenatal testing for conditions like trisomy 21, 18, and 13.
  • A systematic review analyzed 9 studies to assess dPCR's effectiveness, showing high pooled sensitivity (98%) and specificity (99%) for trisomy 21 when compared to traditional karyotyping.
  • The results indicate dPCR is a promising alternative to next-generation sequencing for prenatal testing, although more research is needed to confirm its effectiveness for trisomies 18 and 13.
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  • This study looked at how a medicine called esketamine might help prevent Postpartum Depression (PPD) in women who had a Cesarean Section (C/S)!
  • The researchers found that women who took esketamine had lower rates of PPD and less depression after their surgery compared to those who didn't take it!
  • The conclusion suggests that using esketamine could be a good idea for helping new moms feel better after giving birth, especially after C/S!
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  • - This study aimed to compare the effectiveness of two Letrozole regimens against methotrexate in treating ectopic pregnancy among 88 women with low beta-human chorionic gonadotropin levels.
  • - Participants were divided into three groups: methotrexate, 5-day Letrozole, and 10-day Letrozole, with treatment response assessed by achieving a negative serum beta level without further treatment or surgery.
  • - Results showed that the treatment response rates were similar across all groups (76.7% for methotrexate, 75.0% for 5-day Letrozole, and 90.5% for 10-day Letrozole), indicating no significant differences, and only a small
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Purpose: Laryngeal and Hypopharyngeal Carcinomas (LC/HPC) constitute about 24 % of head and neck cancers, causing more than 90,000 annual deaths worldwide. Diffusion-Weighted Imaging (DWI), is currently widely studied in oncologic imaging and can aid in distinguishing cellular tumors from other tissues. Our objective was to review the effectiveness of DWI in three areas: diagnosing, predicting prognosis, and predicting treatment response in patients with LC/HPC.

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Objective: To evaluate the clinical outcomes of laparoscopic and hysteroscopic surgical approaches for treating symptomatic isthmocele and identify their associated factors.

Materials And Methods: Forty-six patients with symptomatic isthmocele diagnosed using transvaginal saline infusion sonohysterography were enrolled in this prospective cohort study. Patients underwent either laparoscopic or hysteroscopic isthmoplasty based on their residual myometrial thicknesses and fertility desires and were subsequently followed by clinical and ultrasonographic examinations.

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Background: Schizophrenia spectrum disorders (SSD) can be associated with an increased risk of violent behavior (VB), which can harm patients, others, and properties. Prediction of VB could help reduce the SSD burden on patients and healthcare systems. Some recent studies have used machine learning (ML) algorithms to identify SSD patients at risk of VB.

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Objectives: To evaluate the effectiveness of the first-line medical management with Methotrexate (MTX) in the treatment of patients with stable tubal Ectopic Pregnancies (EPs) and varying ranges of Beta-Human Chorionic Gonadotropin (β-HCG) levels.

Materials And Methods: In this retrospective cohort study, we reviewed the medical records of a total of 184 patients with the diagnosis of tubal EP, who received MTX as their first-line treatment. Patients with a baseline β-HCG< 4800 mIU/mL received single-dose MTX (n = 136) and those with an initial β-HCG≥ 4800 mIU/mL underwent the double-dose MTX regimen (n = 48).

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Objectives: Caffeine's potential benefits on multiple sclerosis (MS), as well as on the ambulatory performance of non-MS populations, prompted us to evaluate its potential effects on balance, mobility, and health-related quality of life (HR-QoL) of persons with MS (PwMS).

Methods: This single-arm pilot clinical trial consisted of a 2-week placebo run-in and a 12-week caffeine treatment (200 mg/day) stage. The changes in outcome measures during the study period (weeks 0, 2, 4, 8, and 12) were evaluated using the Generalized Estimation Equation (GEE).

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Background: The early years after the onset of psychotic disorders, known as "early psychosis" (EP) are critical to determining the path of psychosis trajectory. We used a Diffusion Magnetic Resonance Imaging (DMRI) connectometry approach to assess the microstructural changes of white matter (WM) associated with EP.

Methods: We used the Human Connectome Project in Early Psychosis (HCP-EP) dataset to collect DMRI data from patients with EP.

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