Integrated analysis of lncRNA and mRNA expression profiles in cutaneous leishmaniasis lesions caused by .

Background: Cutaneous leishmaniasis (CL), caused by () species, remains a neglected tropical disease in many developing countries. We and others have shown that different species can alter the gene expression profile of human host cells. Long non-coding RNAs (lncRNAs) have been found to play a role in the pathogenesis of leishmaniasis through dysregulation of transcriptome signatures.

Intralesional gene expression profile of JAK-STAT signaling pathway and associated cytokines in infected patients.

Background: The JAK-STAT signaling pathway is a central cascade of signal transduction for the myriad of cytokines in which dysregulation has been implicated in progression of inflammatory and infectious diseases. However, the involvement of this pathway in human cutaneous leishmaniasis (CL) due to () tropica warrants further investigation.

Methods: This study sought to investigate differential gene expression of several cytokines and their associated genes in the lesions of -infected patients byquantitative Real-Time PCR.