Antibacterial and antibiofilm activity of silver nanoparticles stabilized with C-phycocyanin against drug-resistant and .

Background: Biofilms are bacterial communities that can protect them against external factors, including antibiotics. In this study, silver nanoparticles (AgNPs) were formed by modifying AgNPs with C-phycocyanin (Ag-Pc) to inhibit the growth of carbapenem-resistant (CR ) and methicillin-resistant (MRSA) and destroy biofilm of these bacteria.

Methods: The AgNPs were prepared with the green synthesis method, and Pc was used to stabilize the AgNPs.

Factors influencing the antimicrobial mechanism of chitosan action and its derivatives: A review.

Chitosan, a versatile amino polysaccharide biopolymer derived from chitin, exhibits broad-spectrum antimicrobial activity against various pathogenic microorganisms, including gram-negative and gram-positive bacteria, as well as fungi. Due to its ubiquitous use in medications, food, cosmetics, chemicals, and crops, it is an effective antibacterial agent. However, the antimicrobial performance of chitosan is influenced by multiple factors, which have been extensively investigated and reported in the literature.

Vancomycin and nisin-modified magnetic FeO@SiO nanostructures coated with chitosan to enhance antibacterial efficiency against methicillin resistant Staphylococcus aureus (MRSA) infection in a murine superficial wound model.

Background: The objective of this research was to prepare some FeO@SiO@Chitosan (CS) magnetic nanocomposites coupled with nisin, and vancomycin to evaluate their antibacterial efficacy under both in vitro and in vivo against the methicillin-resistant Staphylococcus. aureus (MRSA).

Methods: In this survey, the FeO@SiO magnetic nanoparticles (MNPs) were constructed as a core and covered the surface of MNPs via crosslinking CS by glutaraldehyde as a shell, then functionalized with vancomycin and nisin to enhance the inhibitory effects of nanoparticles (NPs).

Emergence of tigecycline-resistant Klebsiella pneumoniae ST11 clone in patients without exposure to tigecycline.

Introduction: Tigecycline is a unique class of semi-synthetic glycylcyclines developed to treat infections caused by multidrug-resistant Klebsiella pneumoniae. In the past decades, eight tigecycline-resistant Acinetobacter baumannii isolates have been identified in Tehran and no Klebsiella pneumoniae has been reported.

Methodology: To elucidate the mechanism of K.

A Comprehensive Study of the Relationship between the Production of -Lactamase Enzymes and Iron/Siderophore Uptake Regulatory Genes in Clinical Isolates of .

Background: The iron/siderophore uptake system (IUS) involved in the pathogenicity. However, IUS's role in antibiotic resistance and the production of -lactamase enzymes of are unclear. This study aimed to investigate the relationship between the production of -lactamase enzymes and IUS regulatory genes in clinical isolates of .

Improved antibacterial function of Rifampicin-loaded solid lipid nanoparticles on Brucella abortus.

The objective of this study was to assess the antibacterial activity of Rifampicin-loaded solid lipid nanoparticles on Brucella abortus 544. Rifampicin-loaded solid lipid nanoparticles were prepared by a modified microemulsion/sonication method and characterized. The results showed the average size about 319.