The prevalence of metabolically healthy obesity and its transition into the unhealthy state: A 5-year follow-up study.

People with metabolically healthy obesity (MHO) are at risk of developing cardiometabolic diseases. We investigated the prevalence of MHO and factors influencing its transition into a metabolically unhealthy state (MUS). This study was conducted as part of the Kerman Coronary Artery Disease Risk Factor Study (KERCADRS).

Evaluation of foot self-care status and foot screening problems in patients with diabetes in Iran: a national multicenter study.

Background And Purpose: The lack of timely foot care among individuals with diabetics often lead to ulceration followed by infection and amputation. This study aimed to evaluate the foot self-care status and foot screening practices among patients with type 2 diabetes in various cities across Iran.

Methods: The cross-sectional descriptive study was performed on patients with type 2 diabetes in 10 main cities of Iran.

Investigating the Relationship between Carotid Intima-Media Thickness (CIMT), Opium Addiction, and Components of the Metabolic Syndrome.

Background: Atherosclerosis has an essential role in causing cardiovascular diseases. Various factors affect the risk of coronary artery atherosclerosis, and the increase in the carotid intima-media thickness (CIMT) is a primary marker for detecting atherosclerotic changes in the artery wall. Since opioid use is one of the leading social and health problems in many countries, this study aimed to detect the factors influencing the increase in CIMT in opium consumers.

The association between early maladaptive schemas and glycaemic control in patients with type 2 diabetes mellitus: A cross-sectional study.

Introduction: Diabetes is a disease with high prevalence and causes heavy economic burden. Mental and physical health are tied together and their interaction determines one's health or sickness. Early maladaptive schemas (EMSs) are suitable indicators of mental health.

Investigating the relationship between haematological parameters and metabolic syndrome: A population-based study.

Background: Metabolic syndrome (MetS) is a global public health concern. Chronic inflammation plays a role in MetS; haematological inflammatory parameters can be used as MetS predicting factors.

Objective: Hereditary and environmental factors play an important role in the development of MetS.

Empagliflozin induces apoptotic-signaling pathway in embryonic vasculature: and approaches chick's yolk sac membrane model.

The present investigation was conducted to evaluate the vascular-toxicity of empagliflozin (EMP) in embryonic vasculature. Firstly, the vascular-toxicity of the drug as well as its interaction with apoptotic regulator proteins was predicted approach. In the next step, the apoptotic-signaling pathway in embryonic vasculature was evaluated using a chick's YSM model.

Investigating the relationship between serum uric acid to high-density lipoprotein ratio and metabolic syndrome.

Aims: This study aimed to determine a parameter to more easily diagnose metabolic syndrome and predict its probability of occurrence in high-risk individuals.

Methods: In this cross-sectional study, data related to the study population in the Kerman Coronary Artery Disease Risk Factor Study (KERCADRS) were examined. Subjects were divided into two groups with and without metabolic syndrome, and the relevant factors such as the ratios of uric acid to high-density lipoprotein (HDL) (UHR) in these two groups were compared, and the best cut-off point was determined.

The Effect of ThyroidߚStimulating Hormone on Stage of Differentiated Thyroid Carcinoma.

Introduction: Thyroid cancer is the most common endocrine malignancy, and it has the fastest increase rate in incidence in both sexes, with a yearly increase of 3% over the last decade. Thyroid-stimulating hormone (TSH) is the main driver for the thyroid gland to produce thyroid hormone. The main purpose of this study was to assess the relationship between serum TSH level and the stage of malignancy in patients with differentiated thyroid cancer.

Metabolic factors that affect health-related quality of life in type 2 diabetes patients: a multivariate regression analysis.

Purpose: In the past few decades, an increase in the life span of the population has caused more people to experience chronic diseases, such as type 2 diabetes. Since chronic diseases influence the whole life of patients and do not have a specific remedy, improving their health-related quality of life (HRQoL) becomes more important. The aim of the present study was to investigate the metabolic variables that influenced HRQoL questionnaire scores most significantly among patients with type 2 diabetes.

Comparison of Lipid Ratios to Identify Metabolic Syndrome.

Background: The objective of this study was to compare various lipid ratios for detection of metabolic syndrome (MetS) in the Iranian general population.

Methods: This cross-sectional study involved 5677 subjects aged ≥18 years from the general population in Kerman, Iran. Associations between lipid ratio quartiles and MetS were analyzed using logistic regression models.

Clinical Significance of Serum IL-6 and TNF-α Levels in Patients with Metabolic Syndrome.

Background: Several components of metabolic syndrome (MetS) facilitate its diagnosis, including abdominal obesity, hyperlipidemia, high blood pressure, and insulin resistance. The production of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) seem to be associated with MetS components. The aim of this study was to evaluate the correlation between IL-6 and TNF-α serum levels with MetS and its components.

An Investigation of the Risk Factors of Osteoporosis and the Correlation between Opium Consumption and Osteoporosis in Adults.

Background: Osteoporosis and osteopenia are the most common metabolic bone diseases making the patients vulnerable to bone fragility and fracture. In this study, the association of opium consumption and osteoporosis adjusted for other risk factors was studied.

Methods: In this cross-sectional study, 619 cases including 73 men and 546 women referred to densitometry center in Kerman, Iran, were studied.

Investigating Changes in Serum Biochemical Parameters in Opium Addicts Before and During Addiction Treatment.

Background: Iran is one of the major consumers of opium and opiate substances in the world. Addiction has become a very important issue in the 21 century and an urgent one in Iran. The consumption of this substance leaves a variety of impacts on the human body.

Quality assessment of clinical education services in teaching hospitals located in Kerman, Iran.

Introduction: Clinical education is one of the most important components of the resource generation function of health systems, and it has a very important role in graduates' competency with respect to effective, practical education. This study aimed to assess the quality of clinical services in Kerman's teaching hospitals located in southeastern Iran.

Methods: This cross-sectional study was conducted in 2011 on 303 medical students at different levels of medical education at Kerman's teaching hospitals.

Fasting Blood Glucose and Insulin Level in Opium Addict versus Non-Addict Individuals.

Background: Many of lay person believe that opium lowers blood glucose. However some studies show the opposite results. In this study, we tried to evaluate the effect of opium on blood glucose and insulin resistance.

Prevalence of metabolic syndrome in patients with minor beta thalassemia and its related factors: a cross-sectional study.

Background: Atherosclerotic disorders, hypertension and lipid profile alterations are of a lower prevalence in patients with minor beta thalassemia. On the other hand, nowadays, metabolic syndrome is considered as one of the major risk factors of developing cardiovascular diseases. Therefore, the present study was performed to determine the prevalence of metabolic syndrome in patients with minor beta thalassemia.

Determination of most suitable cut off point of waist circumference for diagnosis of metabolic syndrome in Kerman.

Objectives: Metabolic syndrome is a determining indicator of cardiovascular diseases and diabetes. Abdominal obesity, determined by measuring waist circumference, is one of the most important criteria for diagnosing this syndrome. This criterion varies between men and women and among different races.

The effect of opium addiction on thyroid function tests.

Background: A number of abnormalities has been identified among drug addicted users especially heroin addicts. However, there are a few studies to assess the opium effects on thyroid hormones. the aim of the present study is to investigate the effect of opium on the thyroid function tests.

Relationship between serum cystatin C and polycystic ovary syndrome.

Background: Polycystic ovary syndrome (PCOS) causes an increased risk of metabolic cardiovascular syndrome. Also, cystatin C serum levels are associated with the risk of cardiovascular events in metabolic syndrome patients.

Objective: To investigate the relationship between cystatin C in PCOS patients.

Association between anti-thyroid peroxidase antibody and asthma in women.

About 8% of the general population suffers from autoimmune diseases, from which 78% are women. One of the most important causes of thyroid diseases is autoimmunity in origin, and it seems that people with thyroid diseases present more signs of asthma. This study was therefore designed to investigate the frequency of autoimmune thyroid diseases in women suffering from bronchial asthma.

A new frameshift MEN1 gene mutation associated with familial malignant insulinomas.

MEN-1 is an autosomal dominant familial cancer syndrome characterized by involvement of parathyroid, enteropancreatic endocrine tissues and the anterior pituitary gland. Malignant insulinomas are rare, and therefore, there are few data regarding their clinical presentation and long-term prognosis. In this report we present a large family with malignant insulinoma and hyperparathyroidism with MEN-1 gene mutation analysis.

Proinflammatory cytokines in response to insulin-induced hypoglycemic stress in healthy subjects.

Hyperglycemic crises of diabetic ketoacidosis and nonketotic hyperglycemia are associated with elevation of counterregulatory hormones and proinflammatory cytokines, markers of lipid peroxidation, and oxidative stress. To investigate if other conditions besides hyperglycemia could evoke such a prompt increase in cytokine levels, lipid peroxidation, and oxidative stress markers, we induced hypoglycemic stress by standard insulin tolerance test and measured proinflammatory cytokines, markers of lipid peroxidation, reactive oxygen species (ROS), and counterregulatory hormones. Insulin tolerance test was performed in 13 healthy male subjects with no history of infection, cardiovascular risk factors, or abnormal glucose.