Publications by authors named "Mohammad-Ali Mohaghegh"

Article Synopsis
  • - The study introduced a new, efficient method to differentiate between liver fluke species, Fasciola hepatica and F. gigantica, using multiplex PCR instead of the traditional PCR-RFLP technique.
  • - Researchers collected 104 samples from Iranian slaughterhouses, identifying 76 samples as F. hepatica and 28 as F. gigantica, achieving an accuracy of 100% for multiplex PCR and 92% for PCR-RFLP.
  • - The multiplex PCR method is highlighted for its convenience, cost-effectiveness, and rapid results, providing conclusive results in just 3 hours from sample collection.
View Article and Find Full Text PDF

Trichomonas vaginalis is an anaerobic protozoan parasite that causes trichomonosis in human. It is one of the most common non-viral sexually transmitted infections. It has been found to be most prevalent in patients referred to sexually transmitted disease clinics.

View Article and Find Full Text PDF

Echinococcosis is a zoonotic disease caused by larval stages of the Echinococcus genus (metastasis). In this study, salicylate-coated Zinc oxide nanoparticles (SA-ZnO-NPs) were fabricated and characterized by SEM, FTIR and XRD analytical techniques. After that, different doses of SA-ZnO-NPs, SA and ZnO-NPs were taken to assess scolicidal potency.

View Article and Find Full Text PDF

It is estimated that one-third of the world's population is infected with Toxoplasma gondii. The purpose of this study was to evaluate the latest status of toxoplasmosis seroprevalence in the general population and pregnant women in the west of Iran. This retrospective cross-sectional study was conducted in 2018.

View Article and Find Full Text PDF
Article Synopsis
  • Carbapenem resistance in Enterobacterales is a significant global health issue.
  • Research in Isfahan, Iran analyzed 96 clinical Enterobacterales species using biochemical tests and PCR to identify antibiotic resistance.
  • Findings revealed multiple carbapenem resistance traits, offering valuable insight into the spread of resistance genes in pathogenic bacteria in Iran.
View Article and Find Full Text PDF
Article Synopsis
  • This study investigated the natural infection rate of sandflies and their associated parasites in two counties of Ilam province, Iran, known for cutaneous leishmaniasis.
  • Researchers collected sandflies using sticky traps over a six-month period and identified the species using morphological and genetic methods, specifically focusing on their kDNA.
  • The findings revealed a high genetic diversity among the parasite isolates, with six distinct clusters identified, suggesting a varied distribution of different clones in the studied area.
View Article and Find Full Text PDF

Leishmaniosis is one of the most important vector borne diseases. Among different forms of the disease, cutaneous leishmaniosis (CL) is the most common. Determining the method of definitive diagnosis for the disease has been the aim of various studies.

View Article and Find Full Text PDF
Article Synopsis
  • Cutaneous leishmaniasis is a significant disease transmitted by sandflies, and this study focused on identifying the sandfly species involved along the Iran-Iraq border.
  • Researchers collected sandflies from two counties in the Ilam province between May and October over three years, identifying a total of 8 species among 5,592 collected specimens.
  • The study found that 3.33% of the tested sandflies were infected, with one species identified as the primary vector for leishmaniasis in that region, highlighting the need for better understanding and control of these vector populations.
View Article and Find Full Text PDF

Toxocarosis is an important emerging zoonotic disease, which is caused by larvae of Toxocara canis and Toxocara cati, the most widely distributed nematode parasites of dogs and cats. The soil, where Toxocara eggs become infective, is the natural source of infection. The aim of this work was to determine the levels of soil contamination with Toxocara spp.

View Article and Find Full Text PDF

Intestinal parasitic infections such as strongyloidosis are more common among individuals with immune deficiency and sometimes accompanied by severe symptoms. The purpose of this cross-sectional study was to evaluate the prevalence of intestinal parasites with focus on strongyloidosis in hospitalized patients. A total number of 566 faecal samples were obtained from different wards and assessed by the use of direct smear, formalin-ether concentration, and agar plate culture procedures in order to find parasitic protozoa and helminthes.

View Article and Find Full Text PDF

Background: The purpose of this study was to determine the prevalence and genotype of spp. in different groups of immunocompromised patients admitted to the referral hospitals in center of Iran during 2015-2016.

Methods: This cross-sectional study was conducted on 346 immunocompromised patients (HIV/AIDS, Lymphoma, Leukemia and organ transplants) in referred hospitals from central parts of Iran including Isfahan, Markazi, Yazd and Chaharmahale Bakhtiari provinces.

View Article and Find Full Text PDF

Background: Leishmania is a protozoan parasite that nests in macrophages and is responsible for the Leishmaniasis disease. In spite of different defense pathways, last strategy of macrophage for killing parasite is apoptosis process. By permeableizing the mitochondrial outer membrane (MOM).

View Article and Find Full Text PDF

Purpose: Cystic echinococcosis (CE), caused by the metacestode of Echinococcus granulosus, is highly endemic over large parts of Iran. The purpose of this study was to investigate the prevalence rate of hydatidosis and mitochondrial cox1 real-time PCR with high-resolution melting curve (HRM) analysis of E. granulosus isolated from human and livestock.

View Article and Find Full Text PDF

Unawareness of canine parasitic diseases among at-risk hosts and an uncontrolled program of stray dog population have caused that zoonotic parasites received great attention in endemic regions of the Middle East. A total of 552 faecal samples were collected between December 2016 to January 2018 from stray (n = 408) and domestic (n = 144) dogs of Iran. All specimens were coproscopically observed following concentration and flotation techniques.

View Article and Find Full Text PDF

Human echinococcosis is an infectious disease caused by tapeworms belonging to the species Echinococcus. This parasite has a worldwide distribution and is considered a neglected tropical disease by the World Health Organization. Due to the diversity of Echinococcus spp.

View Article and Find Full Text PDF

Objectives: Leishmaniasis is one of the main health problems in developing countries, caused by intracellular protozoan parasites of the Leishmania genus. Although research has been successful in discovering vaccines and anti-parasitic drugs like antimony compounds, their side effects like high toxicity, prolonged regeneration, etc., have raised the replacement importance of natural products with antioxidant and antibacterial properties.

View Article and Find Full Text PDF

is the causative agent of infantile visceral leishmaniasis (VL) in the Mediterranean region. Despite developing protective responses, the disease progresses due to many of factors. These include the action of suppressive cytokines, exhaustion of specific T cells, loss of lymphoid tissue, and defective humoral response.

View Article and Find Full Text PDF

Background: Protozoan parasites of the genus Leishmania are etiologic agents which are intracellular pathogens of vertebrates and replicate inside infected macrophages. Leishmania have developed complex strategies to reverse host immune responses in favor of it. One of the major species causing cutaneous involvements is Leishmania major.

View Article and Find Full Text PDF
Article Synopsis
  • - This study evaluated the prevalence of Cryptosporidiosis in 330 hemodialysis patients compared to 150 healthy individuals in central Iran, emphasizing the high risk of infection for those with weakened immune systems.
  • - Results showed that 3% of dialysis patients were infected, compared to only 0.7% of healthy individuals, with significant correlations found between infection rates and various demographic factors like residency, hygiene, and education levels.
  • - The researchers concluded that screening for infections through stool sample testing, especially in patients with prolonged diarrhea, is crucial for timely treatment, and highlighted the need to manage risk factors effectively.
View Article and Find Full Text PDF

Resistance to most antimalarial drugs has encouraged the development of novel drugs. An alternative source for discovering such drugs is natural products. Some species are used in folk medicine for their sedative, tonic and anti-parasitic effects.

View Article and Find Full Text PDF

Cutaneous leishmaniasis is one of the important skin diseases with diverse clinical manifestations. With an incidence of 0.7-1.

View Article and Find Full Text PDF

Phytotherapy can be an alternative for the control of gastrointestinal parasites in human and animals. Coriander ( L.) is a medicinal plant which grown as a spice crop all over the world.

View Article and Find Full Text PDF