Improving the Photostability of Small-Molecule-Based Organic Photovoltaics by Providing a Charge Percolation Pathway of Crystalline Conjugated Polymer.

Photostability of small-molecule (SM)-based organic photovoltaics (SM-OPVs) is greatly improved by utilizing a ternary photo-active layer incorporating a small amount of a conjugated polymer (CP). Semi-crystalline poly[(2,5-bis(2-hexyldecyloxy)phenylene)--(5,6-difluoro-4,7-di(thiophen-2-yl)benzo[][1,2,5]thiadiazole)] (PPDT2FBT) and amorphous poly[(2,5-bis(2-decyltetradecyloxy)phenylene)--(5,6-dicyano-4,7-di(thiophen-2-yl)benzo[][1,2,5]thiadiazole)] (PPDT2CNBT) with similar chemical structures were used for preparing SM:fullerene:CP ternary photo-active layers. The power conversion efficiency (PCE) of the ternary device with PPDT2FBT (Ternary-F) was higher than those of the ternary device with PPDT2CNBT (Ternary-CN) and a binary SM-OPV device (Binary) by 15% and 17%, respectively.

Autophagy, Unfolded Protein Response and Lung Disease.

Acute Respiratory Distress Syndrome is a severe disorder affecting thousands of individuals worldwide. The available medical countermeasures do not sufficiently suppress the unacceptable high mortality rates associated with those in need. Thus, intense efforts aim to delineate the function of the lung endothelium, so to deliver new therapeutic approaches against this disease.

Prevalence of atopic dermatitis, asthma and rhinitis from infancy through adulthood in rural Bangladesh: a population-based, cross-sectional survey.

Objective: Describe the pattern of atopic disease prevalence from infancy to adulthood.

Design: Cross-sectional household survey.

Setting: Community-based demographic surveillance site, Mirzapur, Bangladesh.

Development, phenotypes of immune cells in BTBR TItpr3/J mice.

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that is characterized by a lack of social interaction, decreased verbal and non-verbal communication skills, and stereotyped repetitive behavior. There is strong evidence that a dysregulated immune response may influence neurodevelopment and thus may have a role in the development of ASD. This study focuses on the characterization of immune cell phenotypes in the BTBR TItpr3/J (BTBR) mouse strain, a widely used animal model for autism research.

Luminespib counteracts the Kifunensine-induced lung endothelial barrier dysfunction.

Unfolded protein response (UPR) suppression by Kifunensine has been associated with lung hyperpermeability, the hallmark of Acute Respiratory Distress Syndrome. The present study investigates the effects of the heat shock protein 90 inhibitor Luminespib (AUY-922) towards the Kifunensine-triggered lung endothelial dysfunction. Our results indicate that the UPR inducer Luminespib counteracts the effects of Kifunensine in both human and bovine lung endothelial cells.

Exploring the Potential of T-Cells for a Universal Influenza Vaccine.

Among the four types of influenza viruses, the influenza A strains and their subtypes have been responsible for causing worldwide pandemics and seasonal epidemics [...

Waterless Hand Cleansing with Chlorhexidine during the Neonatal Period by Mothers and Other Household Members: Findings from a Randomized Controlled Trial.

Observational data suggest maternal handwashing with soap prevents neonatal mortality. We tested the impact of a chlorhexidine-based waterless hand cleansing promotion on the behavior of mothers and other household members. In rural Bangladesh in 2014, we randomized consenting pregnant women to chlorhexidine provision and hand cleansing promotion or standard practices.

Protective Mechanism of the Selective Vasopressin V Receptor Agonist Selepressin against Endothelial Barrier Dysfunction.

Sepsis and septic shock are among the most common causes of death in the intensive care unit; advanced therapeutic approaches are thus urgently needed. Vascular hyperpermeability represents a major manifestation of severe sepsis and is responsible for the ensuing organ dysfunction and failure. Vasopressin V receptor (VR) agonists have shown promise in the treatment of sepsis, increasing blood pressure, and reducing vascular hyperpermeability.

Association of baseline white blood cell counts with tuberculosis treatment outcome: a prospective multicentered cohort study.

Objectives: Tuberculosis (TB) is the leading infectious cause of death in the world. Cheaper and more accessible TB treatment monitoring methods are needed. Here, we evaluated white blood cell (WBC) absolute counts, lymphocyte, and monocyte proportions during TB treatment, and characterized their association with treatment failure.

P53 in the impaired lungs.

Our laboratory is focused on investigating the supportive role of P53 towards the maintenance of lung homeostasis. Acute lung injury, acute respiratory distress syndrome, chronic obstructive pulmonary disease, pulmonary fibrosis, bronchial asthma, pulmonary arterial hypertension, pneumonia and tuberculosis are respiratory pathologies, associated with dysfunctions of this endothelium defender (P53). Herein we review the evolving role of P53 towards the aforementioned inflammatory disorders, to potentially reveal new therapeutic possibilities in pulmonary disease.

Component-based face recognition using statistical pattern matching analysis.

The aim of this research is to develop a fusion concept to component-based face recognition algorithms for features analysis of binary facial components (BFCs), which are invariant to illumination, expression, pose variations and partial occlusion. To analyze the features, using statistical pattern matching concepts, which are the combination of Chi-square (CSQ), Hu moment invariants (HuMIs), absolute difference probability of white pixels (AbsDifPWPs) and geometric distance values (GDVs) have been proposed for face recognition. The individual grayscale face image is cropped by applying the Viola-Jones face detection algorithm from a face database having variations in illumination, appearance, pose and partial occlusion with complex backgrounds.

Exfoliating B. mori silk into high aspect ratio nanofibrils facilitated by response surface methodology.

Silk fiber is formed by an assembly of fibrils. The fibrils can be isolated by a top-down mechanical process called microfibrillation and the fibrils are known as microfibrillated silk (MFS). The process involves chopping, milling, enzyme treatment and high-pressure homogenization.

Therapeutic Endoscopy during COVID-19 Pandemic: An Observational Study from Bangladesh.

: Al Mahtab M, Huq AKMF, Rahman MF, Therapeutic Endoscopy during COVID-19 Pandemic: An Observational Study from Bangladesh. Euroasian J Hepato-Gastroenterol 2020;10(1): 47-49.

Effects of Heat Shock Protein 90 Inhibition In the Lungs.

Inhibition of Hsp90 is associated with anti-inflammatory effects. We employed human lung microvascular endothelial cells to investigate the effects of the Hsp90 inhibitors 17-AAG, AUY-922 and 17-DMAG in the unfolded protein response (UPR) and viability of lung cells. Our observations indicate that moderate doses of those compounds trigger the activation of the UPR without inducing lethal effects .

P53 deficiency potentiates LPS-Induced acute lung injury .

Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) represent a significant cause of morbidity and mortality in critically ill hospitalized patients. Emerging evidence suggest that the expression levels of P53 in the lungs are associated with the supportive effects of heat shock protein 90 inhibitors and growth hormone releasing hormone antagonists in the endothelium. In the current study, we employed an model of intratracheal administration of lipopolysaccharides (LPS)-induced ALI to investigate the role of P53 in counteracting LPS-induced lung inflammatory responses.

Molecular docking and dynamics study of natural compound for potential inhibition of main protease of SARS-CoV-2.

Newly emerged SARS-CoV-2 made recent pandemic situations across the globe is accountable for countless unwanted death and insufferable panic associated with co-morbidities among mass people. The scarcity of appropriate medical treatment and no effective vaccine or medicine against SARS-CoV-2 has turned the situation worst. Therefore, in this study, we made a deep literature review to enlist plant-derived natural compounds and considered their binding mechanism with the main protease of SARS-CoV-2 through combinatorial bioinformatics approaches.

What contributes to inappropriate antibiotic dispensing among qualified and unqualified healthcare providers in Bangladesh? A qualitative study.

Background: Over-prescribing and inappropriate use of antibiotics contributes to the emergence of antimicrobial resistance (AMR). Few studies in low and middle-income settings have employed qualitative approaches to examine the drivers of antibiotic sale and dispensing across the full range of healthcare providers (HCPs). We aimed to explore understandings of the use and functions of antibiotics; awareness of AMR and perceived patient or customer demand and adherence among HCPs for human and animal medicine in Bangladesh.

Unfolded protein response in cardiovascular disease.

The unfolded protein response (UPR) is a highly conserved molecular machinery, which protects the cells against a diverse variety of stimuli. Activation of this element has been associated with both human health and disease. The purpose of the current manuscript is to provide the most updated information on the involvement of UPR towards the improvement; or deterioration of cardiovascular functions.

and evaluation of pharmacological activities of (Roxb.).

, locally known as akandaphal in Bangladesh, has some traditional uses. Leaves and stems extracted with pure methanol (MEATL, MEATS) and fractioned by n-hexane (NFATL, NFATS), which was subjected to qualitative phytochemical analysis. The qualitative phytochemical analysis of four extracts showed the presence of secondary metabolites such as alkaloid, carbohydrate, glycosides, flavonoids, phenols, flavonol, and saponins.

Multiclass EEG signal classification utilizing Rényi min-entropy-based feature selection from wavelet packet transformation.

This paper proposes a novel feature selection method utilizing Rényi min-entropy-based algorithm for achieving a highly efficient brain-computer interface (BCI). Usually, wavelet packet transformation (WPT) is extensively used for feature extraction from electro-encephalogram (EEG) signals. For the case of multiple-class problem, classification accuracy solely depends on the effective feature selection from the WPT features.