Publications by authors named "Mohammad Uddin"

Aquatic vegetation species are declining gradually, posing a threat to the stability of aquatic ecosystems. The decline can be controlled with proper monitoring and mapping of the species for effective conservation and management. The Unmanned Ariel Vehicle (UAV) aka Drone can be deployed to comprehensively capture large area of water bodies for effective mapping and monitoring.

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Background And Aims: Schizophrenia (SCZ) is among the most persistent and devastating psychological problems. Different genetic polymorphisms are responsible for the predisposition of SCZ, and we screened (rs2071287, rs204993) and (rs2070673) polymorphisms in this study to find the connection with SCZ development.

Methods: We investigated a total of 420 samples (210 patients and 210 controls) and used the PCR-RFLP technique to genotype all SNPs.

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Background: Empagliflozin is a relatively newer glucose-lowering drug (GLD) with many extra-glycemic benefits. To date, no study has evaluated the efficacy and safety of empagliflozin in Bangladeshi patients with type 2 diabetes mellitus (T2DM).

Objectives: To assess the efficacy and safety of empagliflozin as an add-on to ongoing GLDs in Bangladeshi adults with uncontrolled T2DM.

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  • Significant advances in cancer treatment have led to new options in chemotherapy, radiotherapy, immunotherapy, and targeted therapies, but resistance to these treatments often leads to tumor recurrence and poorer survival rates.
  • Tumor cells utilize multiple mechanisms to develop resistance to anticancer drugs, and current efforts to combat this resistance have seen limited success.
  • The review focuses on the role of mA RNA modification dysregulation in cancer therapy resistance, exploring recent studies and the potential of targeting these modifications to improve treatment outcomes.
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The development of efficient targeted therapies to ameliorate endothelial disorders is of the utmost need, as evident by the devastating outcomes of the recent pandemic. Recent findings suggest that unfolded protein response (UPR) modulates barrier function. In the current study, we reveal that the aforementioned highly conservative mechanism is involved in the protective effects of growth hormone-releasing hormone antagonists (GHRHAnt) in lung injury, both and .

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Introduction Intracerebral hemorrhage (ICH) is a severe subtype of stroke associated with high rates of mortality and morbidity. Accurate early prognostication is essential for optimizing treatment strategies and improving patient outcomes. The ICH score, which includes clinical and imaging variables, is widely used to predict mortality and functional outcomes in ICH patients.

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Background: Rising childhood obesity rates in Asia are adding risk for the future adult burden of obesity and noncommunicable diseases. Weak policies across most Asian countries enable unrestricted marketing of obesogenic foods and beverages to children. Television is the common medium for food marketing to reach this audience.

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Parkinson disease is a neurogenerative disease common in adults and results in different kinds of memory dysfuntions. This study evaluated the monoamine oxidase B (MAO-B) inhibitory potential of kaurane diterpenoids previously isolated from Xylopia aethiopica through comprehensive computational approaches. Molecular docking study and molecular dynamics simulation were used to access the binding mode and interaction of xylopic acid and MAO-B enzyme.

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In recent years, mangrove restoration has gained significant attention due to its carbon storage capacity, role as a pollution sink, and ecological and economic benefits. Moreover, the United Nations Sustainable Development Goals' strategies include mangrove restoration. This review investigates the status of mangrove restoration research and the influence of restoration on trace metal accumulation, speciation, and associated risks in mangrove sediments.

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  • Newcastle disease virus (NDV) genotype VII poses significant threats to poultry, leading to severe health issues and high mortality rates, prompting research into a locally developed inactivated vaccine.
  • The inactivated ND vaccine was compared with commercial live vaccines in a study assessing different vaccination methods and doses, showing that subcutaneous administration of 1.0 ml resulted in the highest antibody levels and efficacy.
  • Findings indicated that the killed-followed-killed vaccination regimen offered the best protection (100%) and sustained immunity, suggesting its effectiveness in managing ND outbreaks in poultry in Bangladesh.
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Preeclampsia (preE) is a hypertensive disorder in pregnancies. It is the third leading cause of mortality among pregnant women and fetuses worldwide, and there is much we have yet to learn about its pathophysiology. One complication includes cerebral edema, which causes a breach of the blood-brain barrier (BBB).

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Viral nervous necrosis (VNN) poses a significant threat to the aquaculture industry, causing substantial losses and economic burdens. The disease, attributed to nervous necrosis viruses within the Betanodavirus genus, is particularly pervasive in the Mediterranean region, affecting various fish species across all production stages with mortality rates reaching 100%. Developing effective preventive measures against VNN is imperative.

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T cell receptor (TCR) engagement triggers T cell responses, yet how TCR-mediated activation is regulated at the plasma membrane remains unclear. Here, we report that deleting the membrane scaffolding protein Flotillin-2 (Flot2) increases T cell antigen sensitivity, resulting in enhanced TCR signaling and effector function in response to weak TCR stimulation. T cell-specific Flot2-deficient mice exhibited reduced tumor growth and enhanced immunity to infection.

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The retina is a critical component of the eye responsible for capturing visual information, making the importance of retinal health for clear vision. Various eye diseases, such as age-related macular degeneration, diabetic retinopathy, and glaucoma, can severely impair vision and even lead to blindness if not detected and treated early. Therefore, automated systems using machine learning and computer vision techniques have shown promise in the early detection and management of these diseases, reducing the risk of vision loss.

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Background: GHRH is produced in the hypothalamus and affects various tissues beyond the pituitary, including the lungs. GHRH antagonists exert anti-inflammatory properties in several experimental models of disease, but their role inprotecting the endothelial barrier during inflammation is less understood. This study investigates the effects ofGHRHAnt on LPS-induced endothelial dysfunction.

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The presence of nitrates in lakes, rivers, and groundwater is common. Anion exchange resins (AER) are polymeric structures that contain functional groups as well as a variety of particle sizes that are used for removing nitrate ions from solutions. This article provides a concise review of the types and properties of AER, synthesis methods, characterization, and environmental applications of AER.

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  • * Conducted in nine health facilities, the study analyzed sputum samples from 1,084 TB patients, revealing a 6.4% general rate of INH resistance, notably higher in patients previously treated for TB.
  • * Findings show that Hr-TB prevalence (4.5%) is more than double that of multi-drug-resistant TB (1.9%), underscoring the need for improved diagnostic methods for timely treatment of INH-resistant cases in the country.
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  • Inducing T-cell activation is essential for vaccine development, and evaluating candidates for their ability to stimulate T-cell proliferation is crucial for determining their safety and effectiveness.
  • The study introduces a high-throughput in vitro overlay assay system allowing for rapid screening of early-stage vaccine formulations, reducing the need for extensive animal testing.
  • Results from the assay demonstrated significant T-cell proliferation in response to nanoparticulate vaccine candidates, revealing important differences based on pathogen type and antigen dosage, thus underscoring its utility in optimizing vaccine formulations.
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Unlabelled: There are no effective therapies to prevent preeclampsia (PE). Pravastatin shows promise by attenuating processes associated with PE such as decreased cytotrophoblast (CTB) migration, aberrant angiogenesis, and increased oxidative stress. This study assesses the effects of pravastatin on hyperglycemia-induced CTB dysfunction.

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The exploration of mechanical motion in molecular crystals under external stimuli is of great interest because of its potential applications in diverse fields, such as electronics, actuation, or sensing. Understanding the underlying processes, including phase transitions and structural changes, is crucial for exploiting the dynamic nature of these crystals. Here, we present a novel organic compound, , consisting of five interconnected aromatic units and two peripheral alkyl chains, which forms crystals that undergo a drastic anisotropic expansion (33% in the length of one of its dimensions) upon thermal stimulation, resulting in a pronounced deformation of their crystal shape.

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The study assessed the quality of four different edible fats and oils using standard analytical techniques. The presence of potentially toxic elements was determined using atomic absorption spectrometry. This study reveals that edible oils function admirably in terms of physical traits such as moisture content, boiling point, melting point, density, and specific gravity.

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Introduction: Although lignin is one of the most naturally abundant biopolymers, the overall status of its utilization has long been subpar. The ability of Lignin to readily self-assemble into nanoparticles, along with its good biocompatibility and minimal toxicity, makes it a perfect agent for nanocarriers and drug delivery.

Method: Hence, in this study, we have attempted to examine lignin nanoparticles (LNPs) as an efficient pH-responsive nanocarrier for gastric-irritant oral NSAID, aspirin.

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Mushroom farming using agri-waste as substrates can offer a sustainable solution to the food security challenges of inadequate and imbalanced diets. Developing strategies to exploit the potential of the mushroom industry fully is yet to be explored in Bangladesh. We, thus, conducted this study to investigate the challenges and opportunities associated with mushroom farming, as well as the characteristics of farms and employees engaged in this industry.

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  • L. is a medicinal plant being studied for its potential effects on Alzheimer's disease (AD), with a focus on its leaves and flowers, using various methanol, ethanol, and ethyl extracts.
  • Molecular docking studies identified three key phytochemicals—protoberberine, protopine, and codeine—that show strong binding affinities and the ability to target multiple enzymes involved in AD, such as AChE and BACE-1.
  • The extracts demonstrated promising antioxidant and anti-cholinesterase activities, supporting the hypothesis of L.'s anti-AD properties, but further validation is recommended for a complete assessment.
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Background: Around one-quarter of the global population has latent tuberculosis infection (LTBI). If left untreated, LTBI has 5-10% lifetime risk of developing into TB. Interferon-gamma release Assays (IGRAs) are more sensitive than the tuberculin skin test for LTBI detection.

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