Publications by authors named "Mohammad Turhan Pathan"
Article Synopsis
- Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer primarily linked to Merkel cell polyomavirus (MCPyV), which promotes tumor growth through its large T (LT) antigens.
- The study aims to identify small natural antiviral compounds that can inhibit the proliferation of MCC by targeting the LT protein, using advanced computational drug design techniques.
- From screening 2,190 phytochemicals, five promising compounds were identified with high binding energy values, highlighting their potential as therapeutic agents against MCPyV-related cancers.
Bone morphogenetic protein 1 (BMP1) is a secreted metalloprotease of the astacin M12A family of bone morphogenetic proteins (BMPs). BMP1 activates transforming growth factor-β (TGF-β) and BMP signaling pathways by proteolytic cleavage, which has dual roles in gastrointestinal tumor development and progression.TGF-β promotes invasion and metastasis of gastric cancer (GC) by the help of BMP1, so upregulation of the BMP1 may increase cancer invasiveness in GC.
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