Computational modeling of blood clot lysis considering the effect of vessel wall and pulsatile blood flow.

Stroke is one of the major causes of global death, which can occur due to blockage in a blood vessel by a clot. The immediate dissolving of the clot is essential to restore the blood flow and prevent tissue necrosis. Clot dissolution can be achieved via thrombolytic therapy using plasminogen activators.

Numerical and experimental evaluation of ultrasound-assisted convection enhanced delivery to transfer drugs into brain tumors.

Central Nervous System (CNS) malignant tumors are a leading cause of death worldwide with a high mortality rate. While numerous strategies have been proposed to treat CNS tumors, the treatment efficacy is still low mainly due to the existence of the Blood-Brain Barrier (BBB). BBB is a natural cellular layer between the circulatory system and brain extracellular fluid, limiting the transfer of drug particles and confining the routine treatment strategies in which drugs are released in the blood.

Time-domain ultrasound as prior information for frequency-domain compressive ultrasound for intravascular cell detection: A 2-cell numerical model.

This study proposes a new method for the detection of a weak scatterer among strong scatterers using prior-information ultrasound (US) imaging. A perfect application of this approach is in vivo cell detection in the bloodstream, where red blood cells (RBCs) serve as identifiable strong scatterers. In vivo cell detection can help diagnose cancer at its earliest stages, increasing the chances of survival for patients.

Effect of axonal fiber architecture on mechanical heterogeneity of the white matter-a statistical micromechanical model.

A diffusion tensor imaging (DTI) -based statistical micromechanical model was developed to study the effect of axonal fiber architecture on the inter- and intra-regional mechanical heterogeneity of the white matter. Three characteristic regions within the white matter, i.e.

Interaction analysis of a pregnant female uterus and fetus in a vehicle passing a speed bump.

Pregnant vehicle occupants experience relatively large acceleration when the vehicle passes a speed-bump. In this paper, the effect of such sudden acceleration on a pregnant uterus is investigated. A biomechanical model representing the fundamental dynamic behaviors of a pregnant uterus has been developed.

On the mechanical characteristics of graphene nanosheets: a fully nonlinear modified Morse model.

In this paper, the mechanical properties of graphene nanosheets are evaluated based on the nonlinear modified Morse model. The interatomic interactions including stretching and bending of the covalent bonds between carbon atoms, are replaced by nonlinear extensional and torsional spring-like elements. The finite element method is implemented to analyze the model under different loading conditions and linear characteristics of the graphene structure including the Young's modulus, surface modulus, shear modulus and Poisson's ratio are evaluated for various geometries and chirality where these properties are shown to be size and aspect ratio dependent.

Rigid-bar loading on pregnant uterus and development of pregnant abdominal response corridor based on finite element biomechanical model.

During pregnancy, traumas can threaten maternal and fetal health. Various trauma effects on a pregnant uterus are little investigated. In the present study, a finite element model of a uterus along with a fetus, placenta, amniotic fluid, and two most effective ligament sets is developed.

Numerical and Experimental Evaluation of High-Intensity Focused Ultrasound-Induced Lesions in Liver Tissue Ex Vivo.

Objectives: Recent advances in the field of acoustics and piezoelectric and ultrasound transducers have led to new approaches to the diagnosis and treatment of certain diseases. One method of treatment with ultrasonic waves is high-intensity focused ultrasound (HIFU) treatment, which is a thermal therapeutic method used to treat malignant tumors. Although a variety of treatment-planning strategies using ultrasonic waves have been investigated, little clinical success has been achieved.

Simulation of Paramecium Chemotaxis Exposed to Calcium Gradients.

Paramecium or other ciliates have the potential to be utilized for minimally invasive surgery systems, making internal body organs accessible. Paramecium shows interesting responses to changes in the concentration of specific ions such as K(+), Mg(2+), and Ca(2+) in the ambient fluid. Some specific responses are observed as, changes in beat pattern of cilia and swimming toward or apart from the ion source.

Size-dependent characteristics of electrostatically actuated fluid-conveying carbon nanotubes based on modified couple stress theory.

The paper presents the effects of fluid flow on the static and dynamic properties of carbon nanotubes that convey a viscous fluid. The mathematical model is based on the modified couple stress theory. The effects of various fluid parameters and boundary conditions on the pull-in voltages are investigated in detail.