Myeloid derived suppressor cells potentiate virus-specific memory CD8 T cell response.

How therapeutically administered myeloid derived suppressor cells (MDSCs) modulate differentiation of virus-specific CD8 T cell was investigated. In vitro generated MDSCs from bone marrow precursors inhibited the expansion of stimulated CD8 T cells but the effector cells in the recipients of MDSCs showed preferential memory transition during Influenza A virus (IAV) or an α- (Herpes Simplex Virus) as well as a γ- (murine herpesvirus 68) herpesvirus infection. Memory CD8 T cells thus generated constituted a heterogenous population with a large fraction showing effector memory (CD62LCCR7) phenotype.