Evaluation of acute and sub-chronic oral toxicities of Neoneaster in rats.

Ethnopharmacological Relevance: Jaundice is a condition caused by the elevation of bilirubin level in the blood. Due to the neurological and neurodevelopmental sequalae of jaundice in newborns, the high cost of the treatment, and the side effects of the currently used therapies, novel therapeutically approaches are needed. Purgative manna (Shir-e-Khesht) has been used in Persian traditional medicine to reduce serum bilirubin levels of neonates.

Efficacy and safety of date palm leaf-based ointment for treatment of cutaneous warts: A pilot clinical trial.

Despite the considerably high prevalence of cutaneous warts, no optimally effective and safe treatment is available. Leaves of date palm (Phoenix dactylifera L.; Arecaceae) have long been used in Iran's folk medicine as a remedy for warts.

Tonic, Burst, and Burst-Cycle Spinal Cord Stimulation Lead to Differential Brain Activation Patterns as Detected by Functional Magnetic Resonance Imaging.

Objective: The objective of this preclinical study was to examine the responses of the brain to noxious stimulation in the presence and absence of different modes of spinal cord stimulation (SCS) using blood-oxygen-level-dependent functional magnetic resonance imaging (BOLD-fMRI).

Materials And Methods: Sprague-Dawley rats were randomized to groups based on the mode of SCS delivered which included tonic stimulation (n = 27), burst stimulation (n = 30), and burst-cycle stimulation (n = 29). The control (sham) group (n = 28) received no SCS.

Stress-Strength Parameter Estimation under Small Sample Size: A Testing Hypothesis Approach.

In this paper, uniformly most powerful unbiased test for testing the stress-strength model has been presented for the first time. The end of the paper is recommending a method which is appropriate for no large data where a normal asymptotic distribution is not applicable. The previous methods for inference on stress-strength models use almost all the asymptotic properties of maximum likelihood estimators.

Classical and Bayesian Inference of Conditional Stress-Strength Model under Kumaraswamy Distribution.

Stress-strength models have been frequently studied in recent years. An applicable extension of these models is conditional stress-strength models. The maximum likelihood estimator of conditional stress-strength models, asymptotic distribution of this estimator, and its confidence intervals are obtained for Kumaraswamy distribution.

Is urinary β2-microglobulin a reliable marker for assessment of renal tubular dysfunction in chronic hepatitis B patients receiving tenofovir therapy?

Background And Aim: Urinary β2-microglobulin (β2-M) is a marker for renal tubular dysfunction. The current study aimed to assess urinary β2-M as a reliable marker for early prediction of tenofovir disoproxil fumarate (TDF)-related nephrotoxicity among hepatitis B virus (HBV) patients.

Methods: Forty-two HBV patients who were a candidate for TDF therapy or have recently started it (for less than 6 months) were enrolled and subjected to demographic, clinical, laboratory assessment, abdominal ultrasound and transient elastography.

Characterization and application of microalgae hydrochar as a low-cost adsorbent for Cu(II) ion removal from aqueous solutions.

Hydrochar prepared from the hydrothermal liquefaction of microalgae is characterized and investigated for copper removal from aqueous solution. Two hydrochars were prepared at 210 °C (HD210) and 250 °C (HD250). The effect of the initial solution pH, the initial Cu(II) concentration, the contact time, and the temperature will be investigated.

Oral administration of hyperimmune IgY: an immunoecological approach to curbing acute infectious bursal disease virus infection.

Infectious bursal disease (IBD) is one of the most important viral diseases of poultry. Hygienic management and proper vaccination are currently the only economic approach for control of this disease. Attempts have been made to control the disease after the onset of an outbreak using parenteral administration of hyperimmune IgY preparations.