Modulating Mn-doped NiO nanoparticles: structural, optical, and electrical property tailoring for enhanced hole transport layers.

Mn-doped NiO nanoparticles (NPs), denoted as Ni Mn O with values of 0.00, 0.02, 0.

Phase tunable nickel doped MnO nanoparticle synthesis by chemical precipitation: kinetic study on dye degradation.

Nickel (Ni) doped MnO nanoparticles (NPs) were synthesized by a quick and facile chemical precipitation technique to investigate their performance in the degradation of methylene blue (MB) in the absence of light. XRD, FESEM, TEM, AAS, XPS, and FT-IR were used for the investigation of the structural, surface morphological, and elemental composition of Ni doped MnO NPs. XRD confirms the formation of a tetragonal phase structure of pure MnO and 1% and 3% Ni doped MnO NPs.

Revolutionizing Drug Targeting Strategies: Integrating Artificial Intelligence and Structure-Based Methods in PROTAC Development.

PROteolysis TArgeting Chimera (PROTAC) is an emerging technology in chemical biology and drug discovery. This technique facilitates the complete removal of the target proteins that are "undruggable" or challenging to target through chemical molecules via the Ubiquitin-Proteasome System (UPS). PROTACs have been widely explored and outperformed not only in cancer but also in other diseases.

Effect of Reaction Parameters on CO Absorption from Biogas Using CaO Sorbent Prepared from Waste Chicken Eggshell.

This study provides an efficient and straightforward approach to eliminate carbon dioxide (CO) by absorption using a calcium oxide (CaO) sorbent derived from chicken eggshells. The sorbent concentration, stirring speed, and contact time were varied. The optimal condition for CO removal was a 10% calcium hydroxide (Ca(OH)) suspension at 600 rpm with 20 min interaction.

Influence of Sn doping on the optoelectronic properties of ZnO nanoparticles.

Zinc Oxide (ZnO) nanoparticles (NPs) obtained a lot of attention from researchers and industries because of their superior properties as an optoelectronic material. Doping, especially tin (Sn), can further fine-tune their optoelectronic properties. In this manuscript, we have reported the optoelectronic properties of Sn-doped ZnO NPs, which were synthesized by a simple chemical solution method.

Corrigendum: Human Wharton's Jelly stem cell (hWJSC) extracts inhibit ovarian cancer cell lines OVCAR3 and SKOV3 by inducing cell cycle arrest and apoptosis.

[This corrects the article DOI: 10.3389/fonc.2018.

A Review on Carbon Dioxide Minimization in Biogas Upgradation Technology by Chemical Absorption Processes.

With an ever-increasing population and unpredictable climate changes, meeting energy demands and maintaining a sustainable environment on Earth are two of the greatest challenges of the future. Biogas can be a very significant renewable source of energy that can be used worldwide. However, to make it usable, upgrading the gas by removing the unwanted components is a very crucial step.

Numerical Simulation of the Performance of SbSe Solar Cell via Optimizing the Optoelectronic Properties Based SCAPS-1D.

Antimony trisulfide (SbSe), a non-toxic and accessible substance, has possibilities as a material for use in solar cells. The current study numerically analyses SbSe solar cells through the program Solar Cell Capacitance Simulator (SCAPS). A detailed simulation and analysis of the influence of the SbSe layer's thickness, defect density, band gap, energy level, and carrier concentration on the devices' performance are carried out.

Triglyceride Conversion of Waste Frying Oil up to 98.46% Using Low Concentration K/CaO Catalysts Derived from Eggshells.

In this study, biodiesel, also known as fatty acid methyl ester (FAME), was synthesized from multi-stage frying waste soybean oil using chicken eggshell-derived CaO and potassium-impregnated K-CaO heterogeneous catalysts. Potassium-impregnated catalysts (1.25% K-CaO, 2.

A Computational Approach Identified Andrographolide as a Potential Drug for Suppressing COVID-19-Induced Cytokine Storm.

Background: The newly identified betacoronavirus SARS-CoV-2 is the causative pathogen of the coronavirus disease of 2019 (COVID-19) that killed more than 3.5 million people till now. The cytokine storm induced in severe COVID-19 patients causes hyper-inflammation, is the primary reason for respiratory and multi-organ failure and fatality.

Investigating the pathogenic SNPs in BLM helicase and their biological consequences by computational approach.

The BLM helicase protein plays a vital role in DNA replication and the maintenance of genomic integrity. Variation in the BLM helicase gene resulted in defects in the DNA repair mechanism and was reported to be associated with Bloom syndrome (BS) and cancer. Despite extensive investigation of helicase proteins in humans, no attempt has previously been made to comprehensively analyse the single nucleotide polymorphism (SNPs) of the BLM gene.

Middle East respiratory syndrome: pathogenesis and therapeutic developments.

The first case of Middle East respiratory syndrome coronavirus (MERS-CoV) was identified in the year 2012, which spread rapidly and increased to more than 2200 in 2018. This highly pathogenic virus with high mortality rate is among one of the major public health concerns. Saudi Arabia remains to be the most affected region with the majority of MERS-CoV cases, and currently, no effective drugs and vaccines are available for prevention and treatment.

Zika Virus Targeting by Screening Inhibitors against NS2B/NS3 Protease.

Zika flavivirus is suspected to cause Guillain-Barre syndrome in adults and microcephaly, along with other congenital abnormalities in infants. Presently, no vaccines or therapeutics are available. Here, we report novel compounds identified by high-throughput virtual screening of Maybridge chemical database and molecular docking studies.

A comparative study of bacterial diversity based on culturable and culture-independent techniques in the rhizosphere of maize ( L.).

Objective: Maize is an important crop for fodder, food and feed industry. The present study explores the plant-microbe interactions as alternative eco-friendly sustainable strategies to enhance the crop yield.

Methodology: Bacterial diversity was studied in the rhizosphere of maize by culture-dependent and culture-independent techniques by soil sampling, extraction of DNA, amplification of gene of interest, cloning of desired fragment and library construction.

Computational Analysis of Protein Structure Changes as a Result of Nondeletion Insertion Mutations in Human -Globin Gene Suggests Possible Cause of -Thalassemia.

Beta-thalassemia is described as a group of hereditary blood disorders characterized by abnormalities in the synthesis of beta chains of hemoglobin. These anomalies result in different phenotypes ranging from moderate to severe clinical symptoms to no symptoms at all. Most of the defects in hemoglobin arise directly from the mutations in the structural -globin gene Recent advances in computational tools have allowed the study of the relationship between the genotype and phenotype in many diseases including -thalassemia.

Human Wharton's Jelly Stem Cell (hWJSC) Extracts Inhibit Ovarian Cancer Cell Lines OVCAR3 and SKOV3 by Inducing Cell Cycle Arrest and Apoptosis.

Ovarian cancer is a highly lethal and the second highest in mortality among gynecological cancers. Stem cells either naïve or engineered are reported to inhibit various human cancers in both and . Herein we report the cancer inhibitory properties of human Wharton's jelly stem cell (hWJSC) extracts, namely its conditioned medium (hWJSC-CM) and cell lysate (hWJSC-CL) against two ovarian cancer cell lines (OVCAR3 and SKOV3) .

Implications of Isoprostanes and Matrix Metalloproteinase-7 Having Potential Role in the Development of Colorectal Cancer in Males.

Background: Colorectal cancer (CRC) is the third most common type of cancer and leading cause of death worldwide. Major risk factors involved in the development of CRC are increased dietary sources, genetics, and increasing age. Purpose of the study was to find the role of different variables in the progression of CRC.

Prospects of IL-2 in Cancer Immunotherapy.

IL-2 is a powerful immune growth factor and it plays important role in sustaining T cell response. The potential of IL-2 in expanding T cells without loss of functionality has led to its early use in cancer immunotherapy. IL-2 has been reported to induce complete and durable regressions in cancer patients but immune related adverse effects have been reported (irAE).

Comparative study of extrapolative factors linked with oxidative injury and anti-inflammatory status in chronic kidney disease patients experiencing cardiovascular distress.

Background: Chronic kidney disease (CKD) is a group of heterogeneous abnormalities affecting the function and structure of the kidney and mostly further proceeds to cardiovascular damage prior to end stage renal disease (ESRD). The oxidative insult and inflammatory mediators have some undefined role in CKD and cardiovascular complications. It is therefore, aimed at to pin point the predictive factors in the development of cardiovascular disorder in patients with chronic kidney disease.

Genome analysis of Chlamydia trachomatis for functional characterization of hypothetical proteins to discover novel drug targets.

C. trachomatis is a Gram-negative bacterium that causes trachoma and sexually transmitted disease (STD) Chlamydia in humans. Chlamydial genital infections are the most frequent among all communicable diseases.

Evaluation of Matrix Metalloproteinases, Cytokines and Their Potential Role in the Development of Ovarian Cancer.

Background: Ovarian cancer is the 5th most common cause of deaths in the women among gynecological tumors. There are many growing evidences that stress and other behavioral factors may affect cancer progression and patient survival. The purpose of this study is to determine the key role of matrix metalloproteinases (MMPs), and cytokines in the aggregation and progression of ovarian cancer.

Non-coding RNAs in cancer diagnosis and therapy.

Cancer invasion involves a series of fundamental heterogeneous steps, with each step being distinct in its type regarding its dependence on various oncogenic pathways. Over the past few years, researchers have been focusing on targeted therapies to treat malignancies relying not only on a single oncogenic pathway, but on multiple pathways. Scientists have recently identified potential targets in the human genome considered earlier as non-functional but the discovery of their potential role in gene regulation has put new insights to cancer diagnosis, prognosis and therapeutics.

Spontaneous preterm birth and single nucleotide gene polymorphisms: a recent update.

Background: Preterm birth (PTB), birth at <37 weeks of gestation, is a significant global public health problem. World-wide, about 15 million babies are born preterm each year resulting in more than a million deaths of children. Preterm neonates are more prone to problems and need intensive care hospitalization.

Effect of iron overload on renal functions and oxidative stress in beta thalassemia patients.

To check the amount of cellular damage caused by serial transfusions of blood in thalassemia patients.  Methods: A cross-sectional study was conducted in the University of Lahore, Lahore, Pakistan between August 2012 and December 2012. A total of 43 thalassemia patients underwent at least 10 blood transfusions.

Abstracts from the 3rd International Genomic Medicine Conference (3rd IGMC 2015) : Jeddah, Kingdom of Saudi Arabia. 30 November - 3 December 2015.

O1 Regulation of genes by telomere length over long distances Jerry W. Shay O2 The microtubule destabilizer KIF2A regulates the postnatal establishment of neuronal circuits in addition to prenatal cell survival, cell migration, and axon elongation, and its loss leading to malformation of cortical development and severe epilepsy Noriko Homma, Ruyun Zhou, Muhammad Imran Naseer, Adeel G. Chaudhary, Mohammed Al-Qahtani, Nobutaka Hirokawa O3 Integration of metagenomics and metabolomics in gut microbiome research Maryam Goudarzi, Albert J.